Evidence map›Paper›PMID 39008026›Full record

ArticleCardiology and therapy2024

Pharmacodynamic Comparison of Two Aspirin Formulations in the Caribbean: The ARC Study.

Naveen Seecheran, Penelope McCallum, Kathryn Grimaldos, Priya Ramcharan, Jessica Kawall, Arun Katwaroo, Valmiki Seecheran, Cathy-Lee Jagdeo, Salma Rafeeq, Rajeev Seecheran and 10 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiology and therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06228820 (Aspirin Resistance in Trinidad), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06228820 phase2completednot on this map

Aspirin Resistance in Trinidad: The ART Pilot Study.

TypeinterventionalSponsorThe University of The West IndiesRan2024 to 2024Enrolled48ConditionsPlatelet Dysfunction Due to DrugsArmsAspirin 81Mg Ec Tab
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Naveen SeecheranDepartment of Clinical Medical Sciences, Faculty of Medical Sciences, The University of the West Indies, 2nd Floor, Building #67, Eric Williams Medical Sciences Complex, Mt. Hope, Trinidad and Tobago. NSeecheran@gmail.com.ORCID http://orcid.org/0000-0002-7779-0181
Penelope McCallumDepartment of Medicine, North Central Regional Health Authority, Mt. Hope, Trinidad and Tobago.
Kathryn GrimaldosDepartment of Medicine, North Central Regional Health Authority, Mt. Hope, Trinidad and Tobago.
Priya RamcharanDepartment of Medicine, North Central Regional Health Authority, Mt. Hope, Trinidad and Tobago.
Jessica KawallDepartment of Medicine, Trinidad Institute of Medical Technology, St. Augustine, Trinidad and Tobago.
Arun KatwarooDepartment of Medicine, Trinidad Institute of Medical Technology, St. Augustine, Trinidad and Tobago.
Valmiki SeecheranDepartment of Medicine, North Central Regional Health Authority, Mt. Hope, Trinidad and Tobago.
Cathy-Lee JagdeoDepartment of Medicine, North Central Regional Health Authority, Mt. Hope, Trinidad and Tobago.
Salma RafeeqDepartment of Medicine, North Central Regional Health Authority, Mt. Hope, Trinidad and Tobago.
Rajeev SeecheranDepartment of Medicine, Kansas University Medical Center, Wichita, KS, USA.
Abel Leyva QuertDepartment of Medicine, North Central Regional Health Authority, Mt. Hope, Trinidad and Tobago.
Nafeesah AliDepartment of Medicine, North Central Regional Health Authority, Mt. Hope, Trinidad and Tobago.
Lakshmipathi PeramDepartment of Medicine, North Central Regional Health Authority, Mt. Hope, Trinidad and Tobago.
Shari KhanDepartment of Medicine, North Central Regional Health Authority, Mt. Hope, Trinidad and Tobago.
Fareed AliDepartment of Medicine, North Central Regional Health Authority, Mt. Hope, Trinidad and Tobago.
Shastri MotilalDepartment of Clinical Medical Sciences, Faculty of Medical Sciences, The University of the West Indies, 2nd Floor, Building #67, Eric Williams Medical Sciences Complex, Mt. Hope, Trinidad and Tobago.
Neal BhagwandassDepartment of Clinical Medical Sciences, Faculty of Medical Sciences, The University of the West Indies, 2nd Floor, Building #67, Eric Williams Medical Sciences Complex, Mt. Hope, Trinidad and Tobago.
Stanley GiddingsDepartment of Clinical Medical Sciences, Faculty of Medical Sciences, The University of the West Indies, 2nd Floor, Building #67, Eric Williams Medical Sciences Complex, Mt. Hope, Trinidad and Tobago.
Anil RamlackhansinghDepartment of Clinical Medical Sciences, Faculty of Medical Sciences, The University of the West Indies, 2nd Floor, Building #67, Eric Williams Medical Sciences Complex, Mt. Hope, Trinidad and Tobago.
Sherry SandyDepartment of Clinical Medical Sciences, Faculty of Medical Sciences, The University of the West Indies, 2nd Floor, Building #67, Eric Williams Medical Sciences Complex, Mt. Hope, Trinidad and Tobago.

Funding

The University of the West Indies CRP.3.JUN23.04
6 · The paper itself

Abstract

introductionThis prospective, single-arm, crossover pharmacodynamic study assessed the effect of Bayer

methodsForty-seven healthy volunteers were recruited. Platelet function was evaluated with the VerifyNow™ ARU assay (Werfen, Bedford, MA, USA) and assessed post-initiation of Bayer

resultsParticipants on LD EC-ASA had a mean ARU score of 426, with 19.1% of participants having an ARU > 550; patients on LD PL-ASA derived a mean ARU score of 435, with 14.9% achieving an ARU > 550. There were no significant differences in aspirin resistance (ARU > 550) according to the formulation (Bayer

conclusionsThere were no significant differences in aspirin resistance between Bayer

trial registrationClinicalTrials.gov identifier, NCT06228820, prospectively registered 1/18/2024.

Indexed as

AspirinAspirin reaction units (ARU)Aspirin resistanceBayer®Platelet reactivityVazalore®VerifyNow™

Identifiers

PMID39008026
PMCPMC11333668

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.