Evidence map›Paper›PMID 39008141›Full record

ArticleDiscover oncology2024

Therapeutic potential of Buddleja Polystachya Fresen (stem and leaves) extracts: antimicrobial and cytotoxic properties for ocular disease management.

Ali Hendi Alghamdi, Asaad Khalid, Aimun A E Ahmed, Haidar Abdalgadir, Mahadi Bashir, Ashraf N Abdalla, Sami S Ashgar, Hamdi M Alsaid, Magbool E Oraiby

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Discover oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ali Hendi AlghamdiSurgery Department, Faculty of Medicine, Al Baha University, P. O. Box: 1998, Al Baha, 65515, Saudi Arabia. ahsalghamdi@bu.edu.sa.ORCID https://orcid.org/0000-0003-4451-3820
Asaad KhalidHealth Research Center, Jazan University, P. O. Box: 114, Jazan, 82511, Saudi Arabia.ORCID https://orcid.org/0000-0001-8734-2588
Aimun A E AhmedPharmacology Department, Faculty of Medicine, Al Baha University, P. O. Box: 1998, Al Baha, 65515, Saudi Arabia.ORCID https://orcid.org/0000-0002-6403-132X
Haidar AbdalgadirBiology Department, Faculty of Science, Al Baha University, Al Baha, 65515, Saudi Arabia.ORCID https://orcid.org/0000-0002-1497-2412
Mahadi BashirSurgery Department, Faculty of Medicine, Al Baha University, P. O. Box: 1998, Al Baha, 65515, Saudi Arabia.ORCID https://orcid.org/0009-0004-4114-1253
Ashraf N AbdallaDepartment of Pharmacology and Toxicology, College of Pharmacy, Umm Al-Qura University, Makkah, 21955, Saudi Arabia.ORCID https://orcid.org/0000-0003-4770-9319
Sami S AshgarDepartment of medical microbiology, Faculty of medicine, Umm Alqura University, Makka, 21955, Saudi Arabia.
Hamdi M AlsaidDepartment of medical microbiology, Faculty of medicine, Umm Alqura University, Makka, 21955, Saudi Arabia.
Magbool E OraibyPoison Control and Medical Forensic Chemistry Center, Jazan Health Affairs, Ministry of Health, Jazan, Saudi Arabia.

Funding

Deputyship for Research and Innovation, Ministry of Education in Saudi Arabia MOE-BU-4-2020.
6 · The paper itself

Abstract

This study on Buddleja polystachya highlights its phytochemical composition, antimicrobial activity, and cytotoxic impacts. The study emphasizes the plant's potential to treat ocular diseases by identifying important compounds involved in the bioactivity through GC-MS analysis. This study explores the antimicrobial and cytotoxic potential of Buddleja polystachya (stem and leaves) extracts, with a focus on their application in treating bacterial ocular infections and their efficacy against MCF7, HT29, and HepG2 cancer cells. Through comprehensive GC-MS analysis, a diverse array of phytochemicals was identified within Buddleja polystachya stem and leaves extracts, including carbohydrates, phenolic derivatives, fatty acids, and steroidal components. The extracts were then evaluated for their biological activities, revealing significant antimicrobial properties against a range of bacterial strains implicated in ocular infections. The research findings demonstrate that stem extracts derived from Buddleja polystachya demonstrated high to moderate cytotoxic effects on cancer cell lines MCF7, HT29, and HepG2. Notably, these effects were characterized by varying IC

Indexed as

Antimicrobial activityBuddleja Polystachya FresenCytotoxicityGC-MS analysisHepG2HT29MCF7Natural phytochemicalsOcular infections

Identifiers

PMID39008141
PMCPMC11250756

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.