Evidence map›Paper›PMID 39008195›Full record

ArticleThe international journal of cardiovascular imaging2024

Exploring the relationship between epicardial fat and coronary plaque burden and characteristics: insights from cardiac ct imaging.

Venkat Sanjay Manubolu, Julia Ying Lu, Brian Montano, April Kininger, Jassimran Bainiwal, Dhiran Verghese, Luay Alalawi, Jairo Aldana Bitar, Leili Pourafkari, Hooman Fazlalizadeh and 8 more

Abstract read
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In one paragraph

Article in The international journal of cardiovascular imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Venkat Sanjay Manubolu *Lundquist Institute, Harbor UCLA Medical Center, Torrance, CA, 90502, USA.
Julia Ying Lu *Harbor-UCLA Medical Center, 1000 W Carson Street, Box 400, Torrance, CA, 90502, USA. JLu@dhs.lacounty.gov.
Brian MontanoLundquist Institute, Harbor UCLA Medical Center, Torrance, CA, 90502, USA.
April KiningerLundquist Institute, Harbor UCLA Medical Center, Torrance, CA, 90502, USA.
Jassimran BainiwalHarbor-UCLA Medical Center, 1000 W Carson Street, Box 400, Torrance, CA, 90502, USA.
Dhiran VergheseLundquist Institute, Harbor UCLA Medical Center, Torrance, CA, 90502, USA.
Luay AlalawiLundquist Institute, Harbor UCLA Medical Center, Torrance, CA, 90502, USA.
Jairo Aldana BitarLundquist Institute, Harbor UCLA Medical Center, Torrance, CA, 90502, USA.
Leili PourafkariLundquist Institute, Harbor UCLA Medical Center, Torrance, CA, 90502, USA.
Hooman FazlalizadehLundquist Institute, Harbor UCLA Medical Center, Torrance, CA, 90502, USA.
Keishi IchikawaLundquist Institute, Harbor UCLA Medical Center, Torrance, CA, 90502, USA.
Ahmad KhadijeLundquist Institute, Harbor UCLA Medical Center, Torrance, CA, 90502, USA.
Javier DeniseLundquist Institute, Harbor UCLA Medical Center, Torrance, CA, 90502, USA.
Ahmed GhanemLundquist Institute, Harbor UCLA Medical Center, Torrance, CA, 90502, USA.
Sajad HamalLundquist Institute, Harbor UCLA Medical Center, Torrance, CA, 90502, USA.
Song MaoLundquist Institute, Harbor UCLA Medical Center, Torrance, CA, 90502, USA.
Matthew J BudoffLundquist Institute, Harbor UCLA Medical Center, Torrance, CA, 90502, USA.
Sion K RoyLundquist Institute, Harbor UCLA Medical Center, Torrance, CA, 90502, USA.

Funding

UCLA/IWI Lundquist Institute Grant Program 90014-17-07
6 · The paper itself

Abstract

Epicardial adipose tissue (EAT) may enhance the risk of coronary artery disease (CAD). We investigated the relationship between EAT density (a maker of local inflammation) and coronary plaque characteristics in stable CAD patients. This study included 123 individuals who underwent coronary artery calcium scan and coronary CT angiography to evaluate CAD. Plaque characteristics were analyzed by semi-automated software (QAngio, Leiden, Netherlands). Non-contrast CT scans were used to measure EAT density (HU) and volume (cc) (Philips, Cleveland, OH). Multivariate regression models were used to evaluate the association of EAT density and volume with different plaque types. The mean (SD) age was 59.4±10.1 years, 53% were male, the mean (SD) EAT density was -77.2±4.6 HU and the volume was 118.5±41.2 cc. After adjustment for cardiovascular risk factors, EAT density was associated with fibrous fatty (FF) plaque (p<0.03). A 1 unit increase in HU was associated with a 7% higher FF plaque, and lower EAT density is independently associated to FF plaque. The association between EAT density and fibrous (p=0.08), and total noncalcified (p=0.09) plaque trended toward but did not reach significance. There was no association between EAT volume and any plaque type. These results suggest that inflammatory EAT may promote coronary atherosclerosis. Therefore, non-contrast cardiac CT evaluation of EAT quality can help better assess cardiovascular risk.

Indexed as

Adipose TissueAdiposityComputed Tomography AngiographyCoronary AngiographyCoronary Artery DiseaseCoronary VesselsPericardiumPlaque, AtheroscleroticPredictive Value of TestsAgedEpicardial Adipose TissueFemaleFibrosisHumansMaleMiddle AgedAtherosclerosisCardiac CTEpicardial fatEpicardial fat densityEpicardial fat volume

Identifiers

PMID39008195

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.