Evidence map›Paper›PMID 39008201›Full record

ArticleEndocrine2024

A comparison of brown fat tissue related hormone levels in metabolically healthy and unhealthy individuals with obesity.

Hacer Hicran Mutlu, Saniye Koç Ada, Mehmet Uzunlulu, Hasan Hüseyin Mutlu, Mehmet Sargın, Aytekin Oğuz

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Endocrine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hacer Hicran Mutlu *Department of Family Medicine, Faculty of Medicine, Istanbul Medeniyet University, Istanbul, Turkey. hicranbeyca@hotmail.com.ORCID 0000-0003-3712-0068
Saniye Koç Ada *Department of Biochemistry, Faculty of Medicine, Istanbul Medeniyet University, Istanbul, Turkey.ORCID 0000-0003-4927-6625
Mehmet Uzunlulu *Department of Internal Medicine, Faculty of Medicine, Istanbul Medeniyet University, Istanbul, Turkey.ORCID 0000-0001-8754-1069
Hasan Hüseyin Mutlu *Department of Family Medicine, Faculty of Medicine, Health Sciences University, Istanbul, Turkey.ORCID 0000-0001-8947-711X
Mehmet Sargın *Department of Family Medicine, Faculty of Medicine, Istanbul Medeniyet University, Istanbul, Turkey.ORCID 0000-0001-6112-2018
Aytekin Oğuz *Department of Internal Medicine, Faculty of Medicine, Istanbul Medeniyet University, Istanbul, Turkey.ORCID 0000-0002-2595-5167

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeOne of the key functions of brown adipose tissue is its positive impact on metabolism. This study aimed to examine the potential involvement of brown fat-related hormones in the development of metabolically healthy obesity. Specifically, we sought to compare the levels of NRG4, FGF21, and irisin between metabolically healthy and unhealthy individuals with obesity.

methodsPatients with BMI ≥ 30 kg/m

resultsMetabolically healthy and unhealthy obese groups were similar in terms of age and gender. There was no difference between the two groups in terms of BMI, weight, total body fat, muscle, fat-free mass, distribution of body fat and muscle mass. No statistically significant difference was found between irisin, NRG4, and FGF21 levels between metabolically healthy and unhealthy individuals with obesity. It was found that irisin had a significant inverse correlation with BMI and body fat percentage.

conclusionThe present study showed no difference between metabolically healthy and unhealthy obese individuals in terms of irisin, FGF21, and NRG4 levels. The weak association between irisin and BMI and body fat percentage may suggest a potential link between irisin with metabolic health.

Indexed as

Adipose Tissue, BrownFibroblast Growth FactorsFibronectinsNeuregulinsObesityAdultBody Mass IndexFemaleHumansMaleMiddle AgedObesity, Metabolically BenignYoung AdultFGF21 protein, humanFibroblast Growth FactorsFibronectinsFNDC5 protein, humanneuregulin-4NeuregulinsBrown adipose tissueBrowning agentsMetabolic syndromeMetabolismObesityWhite adipose tissue

Identifiers

PMID39008201
PMCPMC11554687

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.