SynthesisJournal of medical Internet research2024
Effectiveness of eHealth Interventions in Improving Medication Adherence Among Patients With Cardiovascular Disease: Systematic Review and Meta-Analysis.
Synthesis in Journal of medical Internet research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Effectiveness of eHealth Interventions on Health Outcomes in Adult Patients With Intestinal Stoma: A Systematic Review and Network Meta-Analysis.International journal of nursing practice · 2026Pooled it
- Enhancing treatment adherence in dialysis patients through digital health interventions: a systematic review and meta-analysis of randomized controlled trials.Renal failure · 2025Pooled it
- Effectiveness of eHealth for Medication Adherence in Renal Transplant Recipients: Systematic Review and Meta-Analysis.Journal of medical Internet research · 2025Pooled it
- Pediatric massage in conjunction with other traditional Chinese medicine therapies for tic disorder in children: systematic review and network meta-analysis.Frontiers in pediatrics · 2025Pooled it
- Engagement With Text Messaging Improves Cardiovascular Medication Adherence: Secondary Analysis of a Randomized Controlled Trial.Journal of medical Internet research · 2025Trial
- Therapeutic approaches to hypertension: A selective perspective on emerging evidence.Journal of translational internal medicine · 2026Article
- Changes in Cardiovascular Risk Factors After Protocolized Adherence Reinforcement and Treatment Optimization: Results from the OPM Study.Journal of clinical medicine · 2026Article
- Patient Engagement Strategies for Implementing Evidence-Based Care in Atherosclerosis.Current atherosclerosis reports · 2026Review
- Bridging the Gap: Multidisciplinary Decision Making to Address Systemic Barriers in Cardiovascular Care.Current cardiology reports · 2026Review
- Digital health interventions for lipid management in atherosclerotic cardiovascular disease: a systematic review and meta-analysis of randomised controlled trials.EClinicalMedicine · 2026Article
- Medication adherence in vascular prevention: findings from the SIFHON-ADH survey in Argentina.Archives of medical science : AMS · 2026Article
- WHF Roadmap for Integrated Care in People Living with - or at Risk of - Cardiovascular Disease and Multiple Long-Term Conditions.Global heart · 2026Review
- Using the behavior change wheel to develop text messages intervention (MedText-PCI) to promote medication adherence in patients after PCI.Frontiers in digital health · 2026Article
- Six-Month Home-Based Telemedicine Program for Heart Failure and Type 2 Diabetes Patients: Applicability, Usability of Telemonitoring Devices and Apps, and Patient Satisfaction.Healthcare (Basel, Switzerland) · 2025Article
- The effectiveness of eHealth-based cardiovascular disease risk communication: a systematic review and meta-analysis.NPJ digital medicine · 2025Article
- ACHO virtual assistant and digital care delivery for treatment adherence: a qualitative study of care practices and representations among nursing professionals.BMC nursing · 2025Article
- Rasch analysis of the mobile version of the eHealth literacy scale for cardiovascular disease patients.Scientific reports · 2025Article
- Investigating the needs of older adults with type 2 diabetes and conceptualizing a healthy diet management application: a conceptual design.BMC geriatrics · 2025Article
- Key Elements and Theoretical Foundations for the Design and Delivery of Text Messages to Boost Medication Adherence in Patients With Diabetes, Hypertension, and Hyperlipidemia: Scoping Review.Journal of medical Internet research · 2025Article
- Self-Management Task Performance and Its Association with Biomarkers in Elderly Patients with Chronic Heart Failure: A Cross-Sectional Analysis.Patient preference and adherence · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNonadherence to medication among patients with cardiovascular diseases undermines the desired therapeutic outcomes. eHealth interventions emerge as promising strategies to effectively tackle this issue.
objectiveThe aim of this study was to conduct a network meta-analysis (NMA) to compare and rank the efficacy of various eHealth interventions in improving medication adherence among patients with cardiovascular diseases (CVDs).
methodsA systematic search strategy was conducted in PubMed, Embase, Web of Science, Cochrane, China National Knowledge Infrastructure Library (CNKI), China Science and Technology Journal Database (Weipu), and WanFang databases to search for randomized controlled trials (RCTs) published from their inception on January 15, 2024. We carried out a frequentist NMA to compare the efficacy of various eHealth interventions. The quality of the literature was assessed using the risk of bias tool from the Cochrane Handbook (version 2.0), and extracted data were analyzed using Stata16.0 (StataCorp LLC) and RevMan5.4 software (Cochrane Collaboration). The certainty of evidence was evaluated using the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) approach.
resultsA total of 21 RCTs involving 3904 patients were enrolled. The NMA revealed that combined interventions (standardized mean difference [SMD] 0.89, 95% CI 0.22-1.57), telephone support (SMD 0.68, 95% CI 0.02-1.33), telemonitoring interventions (SMD 0.70, 95% CI 0.02-1.39), and mobile phone app interventions (SMD 0.65, 95% CI 0.01-1.30) were statistically superior to usual care. However, SMS compared to usual care showed no statistical difference. Notably, the combined intervention, with a surface under the cumulative ranking curve of 79.3%, appeared to be the most effective option for patients with CVDs. Regarding systolic blood pressure and diastolic blood pressure outcomes, the combined intervention also had the highest probability of being the best intervention.
conclusionsThe research indicates that the combined intervention (SMS text messaging and telephone support) has the greatest likelihood of being the most effective eHealth intervention to improve medication adherence in patients with CVDs, followed by telemonitoring, telephone support, and app interventions. The results of these network meta-analyses can provide crucial evidence-based support for health care providers to enhance patients' medication adherence. Given the differences in the design and implementation of eHealth interventions, further large-scale, well-designed multicenter trials are needed.
trial registrationINPLASY 2023120063; https://inplasy.com/inplasy-2023-12-0063/.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.