Evidence map›Paper›PMID 39009880›Full record

ArticleEuropean radiology2025

Structure-function interrelationships and associated neurotransmitter profiles in drug-naïve benign childhood epilepsy with central-temporal spikes patients.

Duoli Chen, Chengxiang Liu, Fuqin Wang, Pengyu Li, Zi Wei, Dingxin Nie, Peng Liu, Heng Liu

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Article in European radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Duoli Chen *School of Life Science and Technology, Xidian University, Xi'an, China.
Chengxiang Liu *School of Life Science and Technology, Xidian University, Xi'an, China.
Fuqin WangDepartment of Radiology, The Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Pengyu LiSchool of Life Science and Technology, Xidian University, Xi'an, China.
Zi WeiSchool of Life Science and Technology, Xidian University, Xi'an, China.
Dingxin NieSchool of Life Science and Technology, Xidian University, Xi'an, China.
Peng LiuSchool of Life Science and Technology, Xidian University, Xi'an, China. liupengphd@gmail.com.ORCID http://orcid.org/0000-0001-6965-8001
Heng LiuDepartment of Radiology, The Affiliated Hospital of Zunyi Medical University, Zunyi, China. zmcliuh@163.com.

Funding

National Natural Science Foundation of China 82270696Young Outstanding Scientific and Technological Talent of Guizhou Province Qiankehepingtairencai[2021]5620
6 · The paper itself

Abstract

objectivesTo explore the interrelationships between structural and functional changes as well as the potential neurotransmitter profile alterations in drug-naïve benign childhood epilepsy with central-temporal spikes (BECTS) patients.

methodsStructural magnetic resonance imaging (sMRI) and resting-state functional MRI data from 20 drug-naïve BECTS patients and 33 healthy controls (HCs) were acquired. Parallel independent component analysis (P-ICA) was used to identify covarying components among gray matter volume (GMV) maps and fractional amplitude of low-frequency fluctuations (fALFF) maps. Furthermore, we explored the spatial correlations between GMV/fALFF changes derived from P-ICA and neurotransmitter maps in JuSpace toolbox.

resultsA significantly positive correlation (p < 0.001) was identified between one structural component (GMV_IC6) and one functional component (fALFF_IC4), which showed significant group differences between drug-naïve BECTS patients and HCs (GMV_IC6: p < 0.01; fALFF_IC4: p < 0.001). GMV_IC6 showed increased GMV in the frontal lobe, temporal lobe, thalamus, and precentral gyrus as well as fALFF_IC4 had enhanced fALFF in the cerebellum in drug-naïve BECTS patients compared to HCs. Moreover, significant correlations between GMV alterations in GMV_IC6 and the serotonin (5HT1a: p < 0.001; 5HT2a: p < 0.001), norepinephrine (NAT: p < 0.001) and glutamate systems (mGluR5: p < 0.001) as well as between fALFF alterations in fALFF_IC4 and the norepinephrine system (NAT: p < 0.001) were detected.

conclusionThe current findings suggest co-altered structural/functional components that reflect the correlation of language and motor networks as well as associated with the serotonergic, noradrenergic, and glutamatergic neurotransmitter systems. CLINICAL RELEVANCE STATEMENT: The relationship between anatomical brain structure and intrinsic neural activity was evaluated using a multimodal fusion analysis and neurotransmitters which might provide an important window into the multimodal neural and underlying molecular mechanisms of benign childhood epilepsy with central-temporal spikes. KEY POINTS: Structure-function relationships in drug-naïve benign childhood epilepsy with central-temporal spikes (BECTS) patients were explored. The interrelated structure-function components were found and correlated with the serotonin, norepinephrine, and glutamate systems. Co-altered structural/functional components reflect the correlation of language and motor networks and correlate with the specific neurotransmitter systems.

Indexed as

Magnetic Resonance ImagingNeurotransmitter AgentsAdolescentBrainCase-Control StudiesChildEpilepsy, RolandicFemaleGray MatterHumansMaleNeurotransmitter AgentsBenign childhood epilepsy with centrotemporal spikesFractional amplitude of low-frequency fluctuationsGray matter volumeNeurotransmitterParallel independent component analysis

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