Evidence map›Paper›PMID 39009893›Full record

Trial reportNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2024

Tibial nerve stimulation in the management of primary sexual dysfunction in patients with multiple sclerosis: a pilot randomized control trial.

Vasileios Giannopapas, Vassiliki Smyrni, Dimitrios K Kitsos, Athanasios K Chasiotis, Konstantina Stavrogianni, Georgia Papagiannopoulou, Georgios Tsivgoulis, Konstantinos Voumvourakis, Sotirios Giannopoulos, Daphne Bakalidou

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Vasileios GiannopapasSecond Department of Neurology, University of Athens, Athens, Greece.
Vassiliki SmyrniSecond Department of Neurology, University of Athens, Athens, Greece.
Dimitrios K KitsosSecond Department of Neurology, University of Athens, Athens, Greece.
Athanasios K ChasiotisSecond Department of Neurology, University of Athens, Athens, Greece.
Konstantina StavrogianniSecond Department of Neurology, University of Athens, Athens, Greece.
Georgia PapagiannopoulouSecond Department of Neurology, University of Athens, Athens, Greece.
Georgios TsivgoulisSecond Department of Neurology, University of Athens, Athens, Greece.
Konstantinos VoumvourakisSecond Department of Neurology, University of Athens, Athens, Greece.
Sotirios GiannopoulosSecond Department of Neurology, University of Athens, Athens, Greece. sgiannop@uoi.gr.ORCID http://orcid.org/0000-0001-7443-5179
Daphne BakalidouDepartment of Physical Therapy, University of West Attica, Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSexual dysfunction (SD) is a common symptom that affects 40-90% of patients with multiple sclerosis (MS). Previous studies have highlighted the negative impact of sexual dysfunction in the mental health status and overall quality of life in patients with MS.

methodsThe aim of this study was to examine the effects of transcutaneous tibial nerve stimulation (TTNS) in the primary SD symptoms in patients with MS. A total of 40 participants were randomized (1:1 ratio) to either TTNS or Sham group and received three 20 min sessions over the course of two months. Pre and post intervention SD was evaluated using the Multiple Sclerosis Intimacy Questionnaire (MISQ-15).

resultsStatistically significant improvements in the aspects of primary sexual dysfunction were observed in the TTNS group pre-post intervention (specifically erectile function (for males)/vaginal lubrication (for females) (p < .001), orgasm quality and satisfaction for both male and female patients (p < .001), sexual desire (p < .05) and bladder related symptomatology (p < .005). In the sham group pre-post intervention, the only observed improvement was in the sexual desire aspect (p < .05). Post intervention the groups significantly differed erectile function/vaginal lubrication and orgasm quality and satisfaction (p < .05).

conclusionsOur findings underline the efficacy of TTNS in improving primary SD symptoms as well as bladder problems in both male and female patients with MS. TTNS demonstrated significant improvement in the following domains: erectile function, vaginal lubrication, orgasm quality, satisfaction, bladder-related symptoms, and sexual desire.

Indexed as

Multiple SclerosisSexual Dysfunction, PhysiologicalTibial NerveTranscutaneous Electric Nerve StimulationAdultFemaleHumansMaleMiddle AgedPilot ProjectsTreatment OutcomeMultiple sclerosisNeuromodulationSexual dysfunctionTranscutaneous nerve stimulation

Identifiers

PMID39009893

What Socratic holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.