Evidence map›Paper›PMID 39009909›Full record

ArticleMolecular diversity2025

Synthesis, characterization and bioactivity of new pyridine-2(H)-one, nicotinonitrile, and furo[2,3-b]pyridine derivatives.

Mohammad M Ibrahim, Mohamad Nurul Azmi, Maram B Alhawarri, Nik Nur Syazni Nik Mohamed Kamal, Hasan AbuMahmoud

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Article in Molecular diversity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mohammad M IbrahimDepartment of Chemistry, Faculty of Science, Al Al-Bayt University, P.O. BOX 130040, Al-Mafraq, 25113, Jordan. mohammadibrahim@aabu.edu.jo.
Mohamad Nurul AzmiSchool of Chemical Sciences, Universiti Sains Malaysia, 11800, Minden, Pulau Pinang, Malaysia.
Maram B AlhawarriDepartment of Pharmacy, Faculty of Pharmacy, Jadara University, P.O.Box 733, Irbid, 21110, Jordan.
Nik Nur Syazni Nik Mohamed KamalDepartment of Toxicology, Advanced Medical and Dental Institute, Universiti Sains Malaysia, 13200, Kepala Batas, Penang, Malaysia.
Hasan AbuMahmoudDepartment of Chemistry, Faculty of Science, Al Al-Bayt University, P.O. BOX 130040, Al-Mafraq, 25113, Jordan.

Funding

Al al-Bayt University REF: Dean's Council Decision No. 331/2022/2023, 10/05/2023
6 · The paper itself

Abstract

Pyridone heterocycles, such as furo[2,3-b]pyridines, have emerged as prominent scaffolds in medicinal chemistry due to their versatile pharmacological properties, including significant anticancer activity. In this study, we successfully synthesized new pyridine-2(H)-one, nicotinonitrile, and furo[2,3-b]pyridine derivatives from chalcones bearing 4-(benzyloxy)phenyl and dichlorothiophenyl subunits to explore their therapeutic potential against breast cancer. By employing a synthetic strategy involving Claisen-Schmidt condensation followed by sequential cyclizations and functional modifications, we synthesized and characterized four compounds (MI-S0, MI-S1, MI-S2, and MI-S3) using various spectroscopic methods, including FT-IR,

Indexed as

Antineoplastic AgentsNitrilesPyridinesBreast NeoplasmsCell Line, TumorCell ProliferationDrug Screening Assays, AntitumorEstrogen Receptor alphaHumansMCF-7 CellsMolecular Docking SimulationProto-Oncogene Proteins c-aktStructure-Activity RelationshipAntineoplastic AgentsEstrogen Receptor alphaNitrilesProto-Oncogene Proteins c-aktPyridinesCytotoxicityMolecular dockingNicotinonitrilePyridine-2(H)-one, Furo[2,3-b]pyridine

Identifiers

PMID39009909

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.