Evidence mapPaperPMID 39010249Full record

ReviewObesity (Silver Spring, Md.)2024

Obesity- and diet-induced plasticity in systems that control eating and energy balance.

Carrie R Ferrario, Heike Münzberg-Gruening, Linda Rinaman, J Nicholas Betley, Stephanie L Borgland, Monica Dus, Debra A Fadool, Kathryn F Medler, Gregory J Morton, Darleen A Sandoval and 7 more

Abstract readReview
In one paragraph

Review in Obesity (Silver Spring, Md.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Adolescent obesity induces sex-specific alterations of action control.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  2. Article
  3. Divergent Roles of Nucleus Accumbens D1- and D2-MSNs in Regulating Hedonic Feeding.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Carrie R FerrarioDepartment of Pharmacology, University of Michigan, Ann Arbor, Michigan, USA.
Heike Münzberg-GrueningLaboratory of Central Leptin Signaling, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
Linda RinamanDepartment of Psychology and Program in Neuroscience, Florida State University, Tallahassee, Florida, USA.
J Nicholas BetleyDepartment of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Stephanie L BorglandDepartment of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada.
Monica DusDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA.
Debra A FadoolDepartment of Biological Science, Program in Neuroscience, Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida, USA.
Kathryn F MedlerSchool of Animal Sciences, Virginia Tech, Blacksburg, Virginia, USA.ORCID 0000-0001-9664-3606
Gregory J MortonDepartment of Medicine, University of Washington Medicine Diabetes Institute at South Lake Union, Seattle, Washington, USA.
Darleen A SandovalDepartment of Pediatrics, Section of Nutrition, University of Colorado-Anschutz Medical Campus, Aurora, Colorado, USA.
Claire B de La SerreDepartment of Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA.
Sarah A StanleyDiabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Kristy L TownsendDepartment of Neurological Surgery, The Ohio State University College of Medicine, Columbus, Ohio, USA.
Alan G WattsDepartment of Biological Sciences, Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, California, USA.
Padma MaruvadaNational Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA.
Diana CummingsNational Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA.
Bradley M CookeNational Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA.ORCID 0000-0003-0989-9684

Funding

Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · 1986 to 2025
$12.6M
PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · UNIVERSITY OF COLORADO DENVER · 1995 to 2025
$7.7M
PILOT STUDY--CLINICAL NUTRITION RESEARCHP30DK035816 · UNIVERSITY OF WASHINGTON · 1986 to 2025
$7.0M
Pilot and Feasibility ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2022 to 2025
$4.9M
Neural control of pancreatic endocrine function in obesity and diabetesR01DK124461 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Sarah Amy Stanley · 2022 to 2024
$1.8M
Deconstruction of a Hypothalamic Exercise-responsive Circuit for NeuroprotectionR01AG079877 · NIA · JACKSON LABORATORY · 2023 to 2025
$1.6M
Pilot and Feasibility (P and F) ProgramP30DK089503 · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2025 to 2025
$1.2M
POSTNATAL DEVELOPMENT OF VAGAL-HYPOTHALAMIC CONNECTIONSR01MH059911 · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 1999 to 2005
$1.2M
Chemosensory Training Program (CTP)T32DC000044 · FLORIDA STATE UNIVERSITY · 1995 to 2025
$832k
Neural Bases of Cephalic Phase Endocrine ResponsesR01DK118910 · NIDDK · FLORIDA STATE UNIVERSITY · PI Alan C Spector, Alan G Watts · 2023 to 2023
$596k
Identifying and characterizing molecular and circuitry-based heterogeneity of AgRP neurons.R01DK124238 · UNIVERSITY OF WASHINGTON · 2025 to 2025
$595k
Defining the functional organization of cerebellar output circuits that control feeding behaviorR01DK124801 · NIDDK · SCINTILLON INSTITUTE FOR PHOTOBIOLOGY · PI John Nicholas Betley, Albert Chen · 2023 to 2023
$569k
Department of Defense HT9425-23-1-0244Department of Defense W81XWH-20-1-0345Intramural NIH HHS Z99 DK999999National Science Foundation 1941822National Science Foundation NSF1949989NCCIH NIH HHS R01 AT011683NIA NIH HHS R01 AG079877NIDCD NIH HHS F31 DC016817NIDCD NIH HHS T32 DC000044NIDDK NIH HHS K26 DK138368NIDDK NIH HHS P01 DK119130NIDDK NIH HHS P30 DK017047NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK035816NIDDK NIH HHS P30 DK089503NIDDK NIH HHS R01 DK089056NIDDK NIH HHS R01 DK092587NIDDK NIH HHS R01 DK100685NIDDK NIH HHS R01 DK118910NIDDK NIH HHS R01 DK121531NIDDK NIH HHS R01 DK121995NIDDK NIH HHS R01 DK124238NIDDK NIH HHS R01 DK124461NIDDK NIH HHS R01 DK124801NIDDK NIH HHS R01 DK125890NIDDK NIH HHS R01 DK130246NIDDK NIH HHS R01 DK130875NIDDK NIH HHS R01 DK133399NIDDK NIH HHS R01 DK133464NIMH NIH HHS R01 MH059911Reported research was supported by DK130246, DK092587, AT011683, MH059911, DK100685, DK119130, DK124801, DK133399, AG079877, DK133464, T32DC000044, F31DC016817, NSF1949989, DK089056, DK124238, DK138368, DK121995, DK125890, DK118910, DK121531, DK124461, DK130875; Canada Research Chair: 950-232211, CIHRFDN148473, CIHRPJT185886; USDA Predoctoral Fellowship; Endowment from the Robinson Family and Tallahassee Memorial Hospital; Department of Defense W81XWH-20-1-0345 and HT9425-23-1-0244; American Diabetes Association #1-17-ACE-31; W.M. Keck Foundation Award; National Science Foundation CAREER 1941822
6 · The paper itself

Abstract

In April 2023, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), in partnership with the National Institute of Child Health and Human Development, the National Institute on Aging, and the Office of Behavioral and Social Sciences Research, hosted a 2-day online workshop to discuss neural plasticity in energy homeostasis and obesity. The goal was to provide a broad view of current knowledge while identifying research questions and challenges regarding neural systems that control food intake and energy balance. This review includes highlights from the meeting and is intended both to introduce unfamiliar audiences with concepts central to energy homeostasis, feeding, and obesity and to highlight up-and-coming research in these areas that may be of special interest to those with a background in these fields. The overarching theme of this review addresses plasticity within the central and peripheral nervous systems that regulates and influences eating, emphasizing distinctions between healthy and disease states. This is by no means a comprehensive review because this is a broad and rapidly developing area. However, we have pointed out relevant reviews and primary articles throughout, as well as gaps in current understanding and opportunities for developments in the field.

Indexed as

DietEnergy MetabolismNeuronal PlasticityObesityAnimalsEatingFeeding BehaviorHomeostasisHumans

Identifiers

PMID39010249
PMCPMC11269035

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.