Evidence map›Paper›PMID 39011107›Full record

ArticleResearch square2024

Mechanism of EHMT2-mediated genomic imprinting associated with Prader-Willi syndrome.

Sung Eun Wang, Yubao Cheng, Jaechul Lim, Mi-Ae Jang, Emily N Forrest, Yuna Kim, Meaghan Donahue, Sheng-Nan Qiao, Yan Xiong, Jian Jin and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Sung Eun WangDepartment of Genetics, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520, USA.
Yubao ChengDepartment of Genetics, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520, USA.
Jaechul LimImmunobiology, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520, USA.
Mi-Ae JangDepartment of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, South Korea.
Emily N ForrestDepartment of Genetics, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520, USA.
Yuna KimSt. Jude Children's Research Hospital, 262 Danny Thomas Place Memphis, TN 38105, USA.
Meaghan DonahueDepartment of Genetics, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520, USA.
Sheng-Nan QiaoDepartment of Genetics, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520, USA.
Yan XiongMount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences, Oncological Sciences and Neuroscience, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Jian JinMount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences, Oncological Sciences and Neuroscience, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0002-2387-3862
Siyuan WangDepartment of Genetics, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520, USA.ORCID 0000-0001-6550-4064
Yong-Hui JiangDepartment of Genetics, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520, USA.ORCID 0000-0001-6188-8806

Funding

Molecular and circuitry mechanism underlying autism behaviors in Shank3 mouse modelsR01MH117289 · NIMH · YALE UNIVERSITY · PI JIANG, YONG-HUI · 2019 to 2023
$3.2M
Genome Architecture in Human Germinal Center B Cell Development, Malignancy, and Somatic HypermutationU01CA260701 · NCI · YALE UNIVERSITY · PI SCHATZ, DAVID G., WANG, SIYUAN · 2020 to 2024
$3.1M
Characterizing the (epi)genetics of oxytocin response in clinical and animal modelsR01HD088007 · NICHD · DUKE UNIVERSITY · PI GREGORY, SIMON G, JIANG, YONG-HUI · 2017 to 2021
$2.9M
Epigenetic Therapy and Prader-Willi SyndromeR01HD088626 · NICHD · YALE UNIVERSITY · PI JIANG, YONG-HUI, JIN, JIAN · 2017 to 2021
$2.8M
Novel Inhibitors of Lysine Methyltransferases G9a and GLP for the Treatment of Alzheimer's DiseaseR01AG084184 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Jian Jin · 2023 to 2026
$2.6M
Building the 3D genomic regulatomeDP2GM137414 · NIGMS · YALE UNIVERSITY · PI WANG, SIYUAN · 2019 to 2019
$2.5M
Integrative single-cell spatial genomic, transcriptomic, and epigenetic imaging in mammalian tissueR01HG011245 · NHGRI · YALE UNIVERSITY · PI WANG, SIYUAN · 2020 to 2023
$2.1M
Therapeutic potential for Prader-Willi syndromeR21HD077197 · NICHD · DUKE UNIVERSITY · PI JIANG, YONG-HUI · 2014 to 2015
$413k
NCI NIH HHS U01 CA260701NHGRI NIH HHS R01 HG011245NIA NIH HHS R01 AG084184NICHD NIH HHS R01 HD088007NICHD NIH HHS R01 HD088626NICHD NIH HHS R21 HD077197NIGMS NIH HHS DP2 GM137414NIMH NIH HHS R01 MH117289
6 · The paper itself

Abstract

Prader-Willi Syndrome (PWS) is caused by loss of expression of paternally expressed genes in the human 15q11.2-q13 imprinting domain. A set of imprinted genes that are active on the paternal but silenced on the maternal chromosome are intricately regulated by a bipartite imprinting center (PWS-IC) located in the PWS imprinting domain. In past work, we discovered that euchromatic histone lysine N-methyltransferase-2 (EHMT2/G9a) inhibitors were capable of un-silencing PWS-associated genes by restoring their expression from the maternal chromosome. Here, in mice lacking the

Identifiers

PMID39011107
PMCPMC11247926

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.