Evidence map›Paper›PMID 39012564›Full record

ArticleMolecular diversity2025

Network pharmacology analysis and molecular mechanism of paeoniflorin and its metabolite in prolactinoma cells.

Min Cao, Lun-Shan Xu, Ping Huang, Bin-Bin Fan, Yi-Hua Zhang

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular diversity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Observational
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Min CaoDepartment of Neurosurgery, Daping Hospital, Army Medical University, Chongqing, China.
Lun-Shan XuDepartment of Neurosurgery, Daping Hospital, Army Medical University, Chongqing, China.
Ping HuangDepartment of Neurosurgery, Daping Hospital, Army Medical University, Chongqing, China.
Bin-Bin FanDepartment of Neurosurgery, Daping Hospital, Army Medical University, Chongqing, China.
Yi-Hua ZhangDepartment of Neurosurgery, Daping Hospital, Army Medical University, Chongqing, China. zhangyihua666@tmmu.edu.cn.

Funding

Natural Science Foundation Project of Chongqing, Chongqing Science and Technology Commission Grant CSTB2023NSCQ-MSX0848
6 · The paper itself

Abstract

Prolactinoma was the most common functional pituitary neuroendocrine tumor tissue type, which was caused by excessive proliferation of pituitary prolactin (PRL) cells. Drug therapy of dopamine receptor agonists was generally considered as the prior treatment for prolactinoma patients. However, there were still prolactinoma patients who were resistant to dopamine agonists. Studies have been reported that paeoniflorin can inhibit the secretion of PRL in prolactinoma cells lacking dopamine D

Indexed as

GlucosidesMonoterpenesNetwork PharmacologyPituitary NeoplasmsProlactinomaAnimalsBridged-Ring CompoundsCell Line, TumorGlycosidesHumansMolecular Docking SimulationProtein Interaction MapsRatsSignal TransductionalbiflorinBridged-Ring CompoundsGlucosidesGlycosidesMonoterpenespeoniflorinAlbiflorinMMP9Network pharmacologyPaeoniflorinProlactinoma

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.