Evidence map›Paper›PMID 39014184›Full record

ArticleScientific reports2024

Associations between diffusion kurtosis imaging metrics and neurodevelopmental outcomes in neonates with low-grade germinal matrix and intraventricular hemorrhage.

Chunxiang Zhang, Meiying Cheng, Zitao Zhu, Kaiyu Wang, Brianna F Moon, Sheng Shen, Bohao Zhang, Zihe Wang, Lin Lu, Honglei Shang and 5 more

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In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Chunxiang ZhangHarvard Medical School, Boston, MA, USA.
Meiying ChengDepartment of Radiology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Zitao ZhuWuhan University, Wuhan, China.
Kaiyu WangGE Healthcare, MR Research China, Beijing, China.
Brianna F MoonHarvard Medical School, Boston, MA, USA.
Sheng ShenHarvard Medical School, Boston, MA, USA.
Bohao ZhangHenan International Joint Laboratory of Neuroimaging, Zhengzhou University, Zhengzhou, China.
Zihe WangZhengzhou University, Zhengzhou, China.
Lin LuDepartment of Radiology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Honglei ShangDepartment of Radiology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Chi QinDepartment of Radiology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Jinze YangDepartment of Radiology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Yu LuDepartment of Radiology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Xiaoan ZhangDepartment of Radiology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Xin ZhaoDepartment of Radiology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China. zhaoxinxct@vip.163.com.

Funding

The National Natural Science Foundation of China 82371929
6 · The paper itself

Abstract

Diffusion Kurtosis Imaging (DKI)-derived metrics are recognized as indicators of maturation in neonates with low-grade germinal matrix and intraventricular hemorrhage (GMH-IVH). However, it is not yet known if these factors are associated with neurodevelopmental outcomes. The objective of this study was to acquire DKI-derived metrics in neonates with low-grade GMH-IVH, and to demonstrate their association with later neurodevelopmental outcomes. In this prospective study, neonates with low-grade GMH-IVH and control neonates were recruited, and DKI were performed between January 2020 and March 2021. These neonates underwent the Bayley Scales of Infant Development test at 18 months of age. Mean kurtosis (MK), radial kurtosis (RK) and gray matter values were measured. Spearman correlation analyses were conducted for the measured values and neurodevelopmental outcome scores. Forty controls (18 males, average gestational age (GA) 30 weeks ± 1.3, corrected GA at MRI scan 38 weeks ± 1) and thirty neonates with low-grade GMH-IVH (13 males, average GA 30 weeks ± 1.5, corrected GA at MRI scan 38 weeks ± 1). Neonates with low-grade GMH-IVH exhibited lower MK and RK values in the PLIC and the thalamus (P < 0.05). The MK value in the thalamus was associated with Mental Development Index (MDI) (r = 0.810, 95% CI 0.695-0.13; P < 0.001) and Psychomotor Development Index (PDI) (r = 0.852, 95% CI 0.722-0.912; P < 0.001) scores. RK value in the caudate nucleus significantly and positively correlated with MDI (r = 0.496, 95% CI 0.657-0.933; P < 0.001) and PDI (r = 0.545, 95% CI 0.712-0.942; P < 0.001) scores. The area under the curve (AUC) were used to assess diagnostic performance of MK and RK in thalamus (AUC = 0.866, 0.787) and caudate nucleus (AUC = 0.833, 0.671) for predicting neurodevelopmental outcomes. As quantitative neuroimaging markers, MK in thalamus and RK in caudate nucleus may help predict neurodevelopmental outcomes in neonates with low-grade GMH-IVH.

Indexed as

Diffusion Tensor ImagingCerebral HemorrhageCerebral Intraventricular HemorrhageChild DevelopmentFemaleGestational AgeGray MatterHumansInfantInfant, NewbornMaleNeurodevelopmental DisordersProspective StudiesDiffusion kurtosis imagingGerminal matrix hemorrhage-intraventricular hemorrhageNeonatesNeurodevelopmental outcomesQuantitative MRI

Identifiers

PMID39014184
PMCPMC11252380

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.