Evidence map›Paper›PMID 39015227›Full record

ArticleCase reports in ophthalmology

Cytomegalovirus Retinitis in an Eye with Unilateral Retinoblastoma: A Case Report.

Leo Meller, Vasan Jagadeesh, Michael Oca, Katherine Wilson, Connor Zuraski, Zachary A Koretz, Patricia Chevez-Barrios, Catherine Liu, Jesse L Berry, Nathan L Scott

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In one paragraph

Article in Case reports in ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Leo MellerSchool of Medicine, University of California, San Diego, CA, USA.
Vasan JagadeeshSchool of Medicine, University of California, San Diego, CA, USA.
Michael OcaSchool of Medicine, University of California, San Diego, CA, USA.
Katherine WilsonSchool of Medicine, University of California, San Diego, CA, USA.
Connor ZuraskiDepartment of Pathology, School of Medicine, University of California, San Diego, CA, USA.
Zachary A KoretzViterbi Family Department of Ophthalmology and Shiley Eye Institute, University of California San Diego, San Diego, CA, USA.
Patricia Chevez-BarriosDepartment of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX, USA.
Catherine LiuViterbi Family Department of Ophthalmology and Shiley Eye Institute, University of California San Diego, San Diego, CA, USA.
Jesse L BerryOcular Oncology and Retinoblastoma Program, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Nathan L ScottViterbi Family Department of Ophthalmology and Shiley Eye Institute, University of California San Diego, San Diego, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Cytomegalovirus (CMV) retinitis in the setting of pediatric retinoblastoma is exceedingly unusual. Here, we present the first reported case of CMV retinitis in an enucleated eye with retinoblastoma after chemotherapy in the western hemisphere. Case Presentation: A 2-year-old Hispanic male without a family history of retinoblastoma presented with a 3-month history of right eye exotropia and squinting. Clinical examination revealed dense white vitreous opacities in the right eye. Ocular oncology evaluation unveiled an exudative retinal detachment with vitreous seeds, subretinal seeding, and a tumor emanating from the retina in the superonasal quadrant of the right eye. The patient was diagnosed with unilateral Group D retinoblastoma, and RB1 sequencing revealed a pathogenic variant with mosaicism. Treatment involved systemic chemotherapy, intravitreal chemotherapy, and cryotherapy. However, the patient developed a rhegmatogenous retinal detachment with diffuse vitreous hemorrhage and ultimately underwent right eye enucleation. Interestingly, histopathological analysis of the enucleated eye revealed concomitant CMV retinitis alongside retinoblastoma. After consultation with infectious disease, antiviral treatment was not initiated as the patient remained asymptomatic and maintained a recovered immune system. Repeat CMV PCR confirmed viral clearance. The patient received a prosthetic eye and continues to be monitored for retinoblastoma recurrence. Conclusion: Clinicians should be aware of the potential for CMV retinitis to develop in retinoblastoma patients receiving chemotherapy, which may complicate clinical decision-making and management. Timely identification of CMV retinitis in this setting may improve patient ocular outcomes and overall prognosis.

Indexed as

Case reportCytomegalovirusPediatricRetinitisRetinoblastoma

Identifiers

PMID39015227
PMCPMC11250386

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.