Evidence map›Paper›PMID 39016063›Full record

ReviewFuture medicinal chemistry2024

Targeted small molecule therapy and inhibitors for lymphoma.

Zhong-Hui Wang, Xiang Zheng, Guo-Wu Rao, Quan Zheng

Abstract readReview
In one paragraph

Review in Future medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Zhong-Hui WangCollege of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, P. R. China.
Xiang ZhengCollege of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, P. R. China.
Guo-Wu RaoCollege of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, P. R. China.ORCID 0000-0002-4223-7191
Quan ZhengCore Facility,The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou 324000, P. R. China.

Funding

National Undergraduate Training Program for Innovation and Entrepreneurship of China 202310337001New-shoot Talents Program of Zhejiang Province 2024R403049Science and Technology Program of Zhejiang Province (Key Innovative Team) 2018R01015
6 · The paper itself

Abstract

Lymphoma, a blood tumor, has become the ninth most common cancer in the world in 2020. Targeted inhibition is one of the important treatments for lymphoma. At present, there are many kinds of targeted drugs for the treatment of lymphoma. Studies have shown that Histone deacetylase, Bruton's tyrosine kinase and phosphoinositide 3-kinase all play an important role in the occurrence and development of tumors and become important and promising inhibitory targets. This article mainly expounds the important role of these target protein in tumors, and introduces the mechanism of action, structure-activity relationship and clinical research of listed small molecule inhibitors of these targets, hoping to provide new ideas for the treatment of lymphoma.

Indexed as

Agammaglobulinaemia Tyrosine KinaseAntineoplastic AgentsLymphomaSmall Molecule LibrariesHistone Deacetylase InhibitorsHistone DeacetylasesHumansMolecular Targeted TherapyPhosphoinositide-3 Kinase InhibitorsProtein Kinase InhibitorsStructure-Activity RelationshipAgammaglobulinaemia Tyrosine KinaseAntineoplastic AgentsHistone Deacetylase InhibitorsHistone DeacetylasesPhosphoinositide-3 Kinase InhibitorsProtein Kinase InhibitorsSmall Molecule LibrariesBTKHDACinhibitorlymphomaPI3K δtreatmenttumor

Identifiers

PMID39016063
PMCPMC11352716

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.