Evidence map›Paper›PMID 39016557›Full record

ArticleJournal of virology2024

Yunrong Gao, Anirudh Raghavan, Sara Andrea Espinosa Garcia, Bowei Deng, Diego Hurtado de Mendoza, Bo Liang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yunrong GaoDepartment of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID 0000-0001-6787-2397
Anirudh RaghavanDepartment of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, USA.
Sara Andrea Espinosa GarciaDepartment of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID 0009-0009-7085-0282
Bowei DengDepartment of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, USA.
Diego Hurtado de MendozaDepartment of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, USA.
Bo LiangDepartment of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID 0000-0002-5617-9228

Funding

Structure and Regulation of The Respiratory Syncytial Virus PolymeraseR01GM130950 · NIGMS · EMORY UNIVERSITY · PI Bo Liang · 2019 to 2026
$3.3M
NIGMS NIH HHS R01 GM130950
6 · The paper itself

Abstract

The respiratory syncytial virus (RSV) M2-1 protein is a transcriptional antitermination factor crucial for efficiently synthesizing multiple full-length viral mRNAs. During RSV infection, M2-1 exists in a complex with mRNA within cytoplasmic compartments called inclusion body-associated granules (IBAGs). Prior studies showed that M2-1 can bind along the entire length of viral mRNAs instead of just gene-end (GE) sequences, suggesting that M2-1 has more sophisticated RNA recognition and binding characteristics. Here, we analyzed the higher oligomeric complexes formed by M2-1 and RNAs

Indexed as

Respiratory Syncytial Virus, HumanRNA, ViralHumansProtein BindingProtein MultimerizationRespiratory Syncytial Virus InfectionsRNA, MessengerViral ProteinsVirus AssemblyRNA, MessengerRNA, ViralViral Proteinselectrophoretic mobility shift assays (EMSA)higher-order oligomerM2-1 proteinmutagenesisnegative stain electron microscopy (EM)respiratory syncytial virus (RSV)RNAsize exclusion chromatography (SEC)

Identifiers

PMID39016557
PMCPMC11334520

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.