Evidence map›Paper›PMID 39018108›Full record

ArticleEnvironmental science & technology2024

Exposure Effects of Environmentally Relevant Concentrations of the Tricyclic Antidepressant Amitriptyline in Early Life Stage Zebrafish.

Sophie L Gould, Matthew J Winter, Maciej Trznadel, Anke Lange, Charles M Hamilton, Rebekah J Boreham, Malcolm J Hetheridge, Andrew Young, William H J Norton, Charles R Tyler

Abstract read
In one paragraph

Article in Environmental science & technology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sophie L GouldBiosciences, Faculty of Health and Life Sciences, University of Exeter, Stocker Road, Exeter, Devon EX4 4QD, U.K.ORCID 0000-0002-6517-5229
Matthew J WinterBiosciences, Faculty of Health and Life Sciences, University of Exeter, Stocker Road, Exeter, Devon EX4 4QD, U.K.
Maciej TrznadelBiosciences, Faculty of Health and Life Sciences, University of Exeter, Stocker Road, Exeter, Devon EX4 4QD, U.K.
Anke LangeBiosciences, Faculty of Health and Life Sciences, University of Exeter, Stocker Road, Exeter, Devon EX4 4QD, U.K.
Charles M HamiltonBiosciences, Faculty of Health and Life Sciences, University of Exeter, Stocker Road, Exeter, Devon EX4 4QD, U.K.ORCID 0000-0002-4717-0643
Rebekah J BorehamBiosciences, Faculty of Health and Life Sciences, University of Exeter, Stocker Road, Exeter, Devon EX4 4QD, U.K.
Malcolm J HetheridgeBiosciences, Faculty of Health and Life Sciences, University of Exeter, Stocker Road, Exeter, Devon EX4 4QD, U.K.
Andrew YoungDepartment of Genetics and Genome Biology, College of Life Sciences, University of Leicester, University Rd., Leicester LE1 7RH, U.K.
William H J NortonDepartment of Genetics and Genome Biology, College of Life Sciences, University of Leicester, University Rd., Leicester LE1 7RH, U.K.
Charles R TylerBiosciences, Faculty of Health and Life Sciences, University of Exeter, Stocker Road, Exeter, Devon EX4 4QD, U.K.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antidepressants are one of the most globally prescribed classes of pharmaceuticals, and drug target conservation across phyla means that nontarget organisms may be at risk from the effects of exposure. Here, we address the knowledge gap for the effects of chronic exposure (28 days) to the tricyclic antidepressant amitriptyline (AMI) on fish, including for concentrations with environmental relevance, using zebrafish (

Indexed as

antidepressantbehaviorbioaccumulationecotoxicologypharmaceuticals

Identifiers

PMID39018108
PMCPMC11295126

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.