Evidence map›Paper›PMID 39018284›Full record

ArticlePloS one2024

Anti-inflammatory effects and beneficial effects of the feed additive Urtica cannabina L. in zebrafish.

Wuyun Liu, Huarong Yu, D Gurbazar, D Rinchindorj, Wei Kang, Chelimuge Qi, Hongsong Chen, Xu Chang, Huan You, Yongmei Han and 3 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Wuyun LiuKey Laboratory of Ecological Agriculture in Horqin Sandy Land, State Ethnic Affairs Commission, Wuhan, China.
Huarong YuKey Laboratory of Ecological Agriculture in Horqin Sandy Land, State Ethnic Affairs Commission, Wuhan, China.
D GurbazarMongolian University of Life Sciences, School of Animal science & Biotechnology, Ulaanbaatar, Mongolia.
D RinchindorjMongolian University of Life Sciences, School of Animal science & Biotechnology, Ulaanbaatar, Mongolia.
Wei KangInner Mongolia Key Laboratory of Toxicant Monitoring and Toxicology, College of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao, Inner Mongolia, China.
Chelimuge QiInner Mongolia Key Laboratory of Toxicant Monitoring and Toxicology, College of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao, Inner Mongolia, China.
Hongsong ChenInner Mongolia Key Laboratory of Toxicant Monitoring and Toxicology, College of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao, Inner Mongolia, China.
Xu ChangInner Mongolia Key Laboratory of Toxicant Monitoring and Toxicology, College of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao, Inner Mongolia, China.
Huan YouTongliao Animal Husbandry Development Center, Tongliao, Inner Mongolia, China.
Yongmei HanInner Mongolia Key Laboratory of Toxicant Monitoring and Toxicology, College of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao, Inner Mongolia, China.
Zhigang LiKey Laboratory of Ecological Agriculture in Horqin Sandy Land, State Ethnic Affairs Commission, Wuhan, China.
Ahmed R GFaculty of Science, Zoology Department, Division of Anatomy and Embryology, Beni-Suef University, Beni-Suef, Egypt.
Wu DongInner Mongolia Key Laboratory of Toxicant Monitoring and Toxicology, College of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao, Inner Mongolia, China.ORCID 0000-0002-2372-2415

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Urtica cannabina L. (UL) has been used clinically for centuries because of its anti-inflammatory properties. This study aimed to investigate the underlying mechanisms and anti-inflammatory effects of different UL concentrations in zebrafish. To elucidate UL's anti-inflammatory properties, two inflammation zebrafish models were designed 1) by severing the zebrafish's caudal fin to assess the repairing effect of UL on the tail inflammation, and 2) by inducing lipopolysaccharides (LPS)-mediated intestinal inflammation to assess the protective and reparative effects of UL on intestinal inflammation at the histological and genetic levels. Furthermore, the effect of UL on the LPS-induced intestinal flora changes was also assessed. After caudal fin resection, a scar formed on the tail of the zebrafish, and the area of the caudal fin increased by 1.30 times as much as that of the control group (P < 0.01). Moreover, this tail scar was alleviated after 10 mg/g UL supplementation but not after 30 mg/g UL dose. LPS decreased the feed intake and body weight of the zebrafish; however, these effects were reversed after 10 and 30 mg/g doses of UL. In addition, the LPS treatment also reduced the intestinal goblet cells by 49% in the zebrafish when compared with the control, which was significantly restored after 10 and 30 mg/g UL treatments. At the genetics level, the expression of the pro-inflammatory cytokine genes (TNF-α, IL6, and IL8) showed that 10 and 30 mg/g UL doses could rescue LPS-induced expression. The gut microbiota analysis revealed changes in the abundance of four major bacterial phyla in the 10 and 30 mg/g UL-treated groups, with an increased probiotic Bacteroidota and decreased pathogenic bacteria. These results indicate that UL strongly inhibits inflammation caused by caudal fin removal and LPS-induced inflammatory changes in the zebrafish intensity, suggesting that UL is a feed additive that could be developed to improve resistance to inflammation in livestock.

Indexed as

Anti-Inflammatory AgentsLipopolysaccharidesZebrafishAnimal FeedAnimalsFood AdditivesGastrointestinal MicrobiomeInflammationPlant ExtractsAnti-Inflammatory AgentsFood AdditivesLipopolysaccharidesPlant Extracts

Identifiers

PMID39018284
PMCPMC11253947

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.