ArticleCell reports. Medicine2024
Aberrant bowel movement frequencies coincide with increased microbe-derived blood metabolites associated with reduced organ function.
Article in Cell reports. Medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Trial
- A Postbiotic ContainingMicroorganisms · 2026Article
- Association between habitual intake of fermented milk products containing lactic acid bacteria and all-cause mortality: a community-based cohort prospective study.The journal of nutrition, health & aging · 2026Article
- Postbiotic Stool Filtrates From Patients With Type 2 Diabetes Impair Mouse Intestinal Muscle Contractility Ex Vivo and Alter Enteric Cholinergic Neuronal Activity in Vivo.Neurogastroenterology and motility · 2026Article
- Species level composition of Faecalibacterium spp. in the gut of Japanese adults revealed by rpoA-based sequencing analysis.FEMS microbiology ecology · 2026Article
- Article
- Metabolomic signatures of extreme old age: findings from the New England Centenarian Study.GeroScience · 2026Article
- Host factors dictate gut microbiome alterations in chronic kidney disease more strongly than kidney function.Nature microbiology · 2026Article
- Effects of liquid diet administration routes and types of dietary fiber pectin on fecal characteristics and gut microbiota in rats.Frontiers in nutrition · 2026Article
- Recent advances in biomarkers for cardiac fibrosis.Frontiers in cardiovascular medicine · 2026Review
- Identifying core symptoms of anxiety and depression in colorectal cancer patients: network analysis.Frontiers in psychiatry · 2026Article
- Machine learning to predict postdialysis fatigue in patients undergoing hemodialysis.Renal failure · 2025Article
- Microbial Feast or Famine: dietary carbohydrate composition and gut microbiota metabolic function.bioRxiv : the preprint server for biology · 2025Article
- Early life gut microbial and metabolic shifts reflected in stool consistency- a gut transit time proxy.bioRxiv : the preprint server for biology · 2025Article
- METABOLOMIC SIGNATURES OF EXTREME OLD AGE: FINDINGS FROM THE NEW ENGLAND CENTENARIAN STUDY.bioRxiv : the preprint server for biology · 2025Article
- Metagenomic estimation of absolute bacterial biomass in the mammalian gut through host-derived read normalization.mSystems · 2025Article
- Association between dietary index for gut microbiota and chronic kidney disease: A cross-sectional study from U.S. population.Preventive medicine reports · 2025Article
- The relationship of cardiometabolic index with bowel movement frequency: an NHANES-based cross-sectional analysis.Lipids in health and disease · 2025Article
- Senility, defecation disorders, sleep disorders, and non-operative spinal infections: A single-center retrospective analysis.World journal of orthopedics · 2025Article
- Metagenomic estimation of absolute bacterial biomass in the mammalian gut through host-derived read normalization.bioRxiv : the preprint server for biology · 2025Article
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Abstract
Bowel movement frequency (BMF) directly impacts the gut microbiota and is linked to diseases like chronic kidney disease or dementia. In particular, prior work has shown that constipation is associated with an ecosystem-wide switch from fiber fermentation and short-chain fatty acid production to more detrimental protein fermentation and toxin production. Here, we analyze multi-omic data from generally healthy adults to see how BMF affects their molecular phenotypes, in a pre-disease context. Results show differential abundances of gut microbial genera, blood metabolites, and variation in lifestyle factors across BMF categories. These differences relate to inflammation, heart health, liver function, and kidney function. Causal mediation analysis indicates that the association between lower BMF and reduced kidney function is partially mediated by the microbially derived toxin 3-indoxyl sulfate (3-IS). This result, in a generally healthy context, suggests that the accumulation of microbiota-derived toxins associated with abnormal BMF precede organ damage and may be drivers of chronic, aging-related diseases.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.