Evidence map›Paper›PMID 39020133›Full record

ArticleMolecular diversity2024

Molecular design of hydroxamic acid-based derivatives as urease inhibitors of Helicobacter pylori.

Na Wang, Xiaoyan Wu, Jianhuai Liang, Boping Liu, Bingfeng Wang

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular diversity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Na WangCollege of Materials and Energy, South China Agricultural University, Guangzhou, 510630, China.
Xiaoyan WuCollege of Materials and Energy, South China Agricultural University, Guangzhou, 510630, China.
Jianhuai LiangCollege of Materials and Energy, South China Agricultural University, Guangzhou, 510630, China.
Boping LiuCollege of Materials and Energy, South China Agricultural University, Guangzhou, 510630, China. boping@scau.edu.cn.
Bingfeng WangCollege of Materials and Energy, South China Agricultural University, Guangzhou, 510630, China. wbfeng@scau.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Helicobacter pylori is the main causative agent of gastric cancer, especially non-cardiac gastric cancers. This bacterium relies on urease producing much ammonia to colonize the host. Herein, the study provides valuable insights into structural patterns driving urease inhibition for high-activity molecules designed via exploring known inhibitors. Firstly, an ensemble model was devised to predict the inhibitory activity of novel compounds in an automated workflow (R

Indexed as

Drug DesignEnzyme InhibitorsHelicobacter pyloriHydroxamic AcidsMolecular Dynamics SimulationUreaseAnti-Bacterial AgentsStructure-Activity RelationshipAnti-Bacterial AgentsEnzyme InhibitorsHydroxamic AcidsUreaseChemical spaceHelicobacter pyloriMachine learningMolecular dynamicsUrease inhibitor

Identifiers

PMID39020133

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.