Evidence map›Paper›PMID 39020160›Full record

ArticleJournal of exposure science & environmental epidemiology2025

Associations of exposure to bisphenol-A or parabens with markers of liver injury/function among US adults in NHANES 2011-2016.

Rongkun Luo, Mingcong Chen, Shuai Hao, Marady Hun, Shaobin Luo, Feizhou Huang, Zhao Lei, Mingyi Zhao

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of exposure science & environmental epidemiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rongkun LuoDepartment of Hepatopancreatobiliary Surgery and Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Mingcong ChenDepartment of Hepatopancreatobiliary Surgery and Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Shuai HaoDepartment of Oncology, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Marady HunDepartment of Hepatopancreatobiliary Surgery and Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Shaobin LuoDepartment of Hepatopancreatobiliary Surgery and Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Feizhou HuangDepartment of Hepatopancreatobiliary Surgery and Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Zhao LeiDepartment of Hepatopancreatobiliary Surgery and Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China. leizhao1987@outlook.com.
Mingyi ZhaoDepartment of Hepatopancreatobiliary Surgery and Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China. zhao_mingyi@csu.edu.cn.ORCID http://orcid.org/0000-0002-2884-0736

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBisphenol-A (BPA) and parabens are common endocrine-disrupting compounds (EDCs) that are used extensively in consumer products worldwide and are widely found in the environment.

objectiveThe purpose of this study was to comprehensively explore the correlations between urinary BPA/parabens levels and liver injury/function markers.

methodsIn this cross-sectional study, we used National Health and Nutrition Examination Survey (NHANES) data from 2011 to 2016. The exposure variables were urinary BPA and four urinary parabens [methylparaben (MPB), ethylparaben (EPB), propylparaben (PPB), and butylparaben (BPB)], while the outcome variables were indicators of liver function/injury [alanine aminotransferase (ALT), aspartate aminotransferase (AST), AST/ ALT, albumin (ALB), total protein (TP), total bilirubin (TBIL), alkaline phosphatase (ALP), and the fibrosis-4 index (FIB-4)]. Multiple linear regression and weighted quantile sum (WQS) regression analyses were applied to explore the relationships between the individual/combined exposure variables and the liver injury/function indicators, respectively. Furthermore, stratified analysis was employed to detect the associations influenced by age and sex.

resultsA total of 2,179 adults were eligible for the present analysis. Multivariate linear regression analysis revealed positive associations of EPB with AST, ALT, TP, and FIB-4 scores and negative associations of BPA with TP and ALB. The effects of urinary parabens on adverse outcomes in the liver (AST and ALT) were significant in the female and middle-aged subgroups. In addition, the WQS analysis revealed that the mixture of four compounds was negatively associated with ALB. BPA had the greatest effect on the serum ALB concentration (weight = 0.688). IMPACT: Our present study provided novel evidence of significant associations between BPA or certain parabens and numerous markers of liver injury/function indicators. We found that higher urinary BPA concentrations were associated with worse liver function. Exposure to high EPB/PPB ratios was significantly associated with biomarkers of liver injury.

Indexed as

Benzhydryl CompoundsChemical and Drug Induced Liver InjuryEndocrine DisruptorsEnvironmental ExposureParabensPhenolsAdultBiomarkersBisphenol A CompoundsCross-Sectional StudiesFemaleHumansLiverMaleMiddle AgedNutrition SurveysBenzhydryl CompoundsBiomarkersbisphenol ABisphenol A CompoundsEndocrine DisruptorsParabensPhenolsBPAChemical mixturesLiver injuryNHANESParabens

Identifiers

PMID39020160

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.