Evidence map›Paper›PMID 39023067›Full record

ArticleJournal of the American Heart Association2024

Inositol 1,4,5-Trisphosphate Receptors Regulate Vascular Smooth Muscle Cell Proliferation and Neointima Formation in Mice.

Fang Huang, Fei Zhang, Lei Huang, Xiangbin Zhu, Can Huang, Na Li, Qingen Da, Yu Huang, Huihua Yang, Hong Wang and 9 more

Abstract read
In one paragraph

Article in Journal of the American Heart Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Conditional deletion of IPJournal of gastroenterology · 2025
    Article
  7. Review
  8. Potential therapeutic mechanisms ofFrontiers in pharmacology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Fang HuangDepartment of Cardiovascular Surgery, Peking University Shenzhen Hospital, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School Peking University Shenzhen China.
Fei ZhangDepartment of Cardiovascular Surgery, Peking University Shenzhen Hospital, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School Peking University Shenzhen China.
Lei HuangDepartment of Cardiovascular Surgery, Peking University Shenzhen Hospital, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School Peking University Shenzhen China.ORCID 0000-0003-2110-2949
Xiangbin ZhuDepartment of Cardiovascular Surgery, Peking University Shenzhen Hospital, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School Peking University Shenzhen China.ORCID 0000-0002-6821-5038
Can HuangDepartment of Cardiovascular Surgery, Peking University Shenzhen Hospital, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School Peking University Shenzhen China.
Na LiDepartment of Cardiovascular Surgery, Peking University Shenzhen Hospital, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School Peking University Shenzhen China.ORCID 0009-0008-6799-3453
Qingen DaDepartment of Cardiovascular Surgery, Peking University Shenzhen Hospital, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School Peking University Shenzhen China.ORCID 0000-0002-1683-9922
Yu HuangDepartment of Cardiovascular Surgery, Peking University Shenzhen Hospital, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School Peking University Shenzhen China.ORCID 0000-0002-4807-4629
Huihua YangDepartment of Cardiovascular Surgery, Peking University Shenzhen Hospital, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School Peking University Shenzhen China.ORCID 0009-0007-8138-4569
Hong WangCentral Laboratory Peking University Shenzhen Hospital Shenzhen China.
Lingyun ZhaoDepartment of Cardiovascular Surgery, Peking University Shenzhen Hospital, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School Peking University Shenzhen China.
Qingsong LinDepartment of Cardiovascular Surgery, Peking University Shenzhen Hospital, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School Peking University Shenzhen China.
Zee ChenDepartment of Cardiovascular Surgery, Peking University Shenzhen Hospital, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School Peking University Shenzhen China.ORCID 0000-0002-1501-2843
Junjie XuDepartment of Cardiovascular Surgery, Peking University Shenzhen Hospital, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School Peking University Shenzhen China.ORCID 0000-0003-4303-7295
Jie LiuDepartment of Pathophysiology, School of Medicine Shenzhen University Shenzhen China.ORCID 0000-0001-5310-7520
Mingming RenDepartment of Cardiovascular Surgery, Peking University Shenzhen Hospital, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School Peking University Shenzhen China.
Yan WangDepartment of Cardiology Qingdao Municipal Hospital Qingdao China.ORCID 0009-0004-0741-2873
Zhen HanDepartment of Cardiovascular Surgery, Peking University Shenzhen Hospital, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School Peking University Shenzhen China.ORCID 0009-0002-6434-5238
Kunfu OuyangDepartment of Cardiovascular Surgery, Peking University Shenzhen Hospital, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School Peking University Shenzhen China.ORCID 0000-0003-0292-375X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVascular smooth muscle cell (VSMC) proliferation is involved in many types of arterial diseases, including neointima hyperplasia, in which Ca METHODS AND

resultsBoth in vitro cell culture models and in vivo mouse models were generated to investigate the role of IP

conclusionsOur results demonstrated an essential role of IP

Indexed as

Cell ProliferationInositol 1,4,5-Trisphosphate ReceptorsMuscle, Smooth, VascularMyocytes, Smooth MuscleNeointimaAnimalsBecaplerminCalciumCalcium SignalingCarotid Artery InjuriesCell MovementCells, CulturedCyclic AMP Response Element-Binding ProteinDisease Models, AnimalEndoplasmic ReticulumMaleBecaplerminCalciumCyclic AMP Response Element-Binding ProteinInositol 1,4,5-Trisphosphate ReceptorsItpr1 protein, mouseProto-Oncogene Proteins c-aktCa2+ signalingcell proliferationIP3 receptorneointima formationvascular remodelingvascular smooth muscle cell

Identifiers

PMID39023067
PMCPMC11964046

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.