ArticleNeurosurgery2025
Changes on Cognition and Brain Network Temporal Variability After Pediatric Neurosurgery.
Article in Neurosurgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Predicting attention deficits and functional recovery after glioma resection through functional executive networks: insights from dynamic properties.Journal of neuro-oncology · 2025Article
- Structural and functional alterations in the contralateral hemisphere following pediatric intracranial surgery: a pilot longitudinal neuroimaging study.Frontiers in human neuroscience · 2025Article
- Hubs, influencers, and communities of executive functions: a task-based fMRI graph analysis.Frontiers in human neuroscience · 2025Article
- Cognitive and cortical network alterations in pediatric temporal lobe space-occupying lesions: an fMRI study.Frontiers in human neuroscience · 2024Article
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Authors and funding
11 authors.
Funding
Abstract
BACKGROUND AND
objectivesPediatric intracranial space-occupying lesions are common, with prognoses improving markedly in recent years, significantly extending survival. As such, there is an imperative to pay increased attention to the postoperative cognitive functions and brain network alterations in these children because these factors significantly influence their quality of life. Temporal variability (TV) analysis of brain networks captures the full extent of resting-state activities, reflecting cognitive functions and rehabilitation potential. However, previous research rarely uses TV analyses and most focus on adults or children after multidisciplinary treatments, not reflecting the combined effect caused by neurosurgery only and self-repair. This study gives our insights into this field from a holistic perspective.
methodsWe studied 35 children with intracranial space-occupying lesions, analyzing pre- and postsurgery MRI and cognitive tests. We used TV analysis to assess changes and correlated imaging indicators with cognitive performance.
resultsWe observed a tendency for cognitive recovery after about 3 months postsurgery, primarily in the domains of social cognition and nonverbal reasoning. TV analysis of brain networks indicated increased nodal variability within systems such as the visual and sensorimotor networks, which are integral to external interactions. Correlative analysis showed that alterations in certain occipital regions were associated with changes in social cognition and nonverbal reasoning.
conclusionThese findings suggest significant intrinsic repair in cognitive functions and brain networks at around 3 months postneurosurgery in children. This study not only enriches our comprehension of postoperative cognitive and brain network self-repair processes in children but also furnishes potential therapeutic targets for rehabilitation interventions and establishes a theoretical foundation for proactive surgical interventions.
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