Evidence map›Paper›PMID 39025061›Full record

ArticleDevelopmental cell2024

Integrated transcriptomics of human blood vessels defines a spatially controlled niche for early mesenchymal progenitor cells.

Yiyun Wang, Neelima Thottappillil, Mario Gomez-Salazar, Robert J Tower, Qizhi Qin, Ishbel Camila Del Rosario Alvia, Mingxin Xu, Masnsen Cherief, Ray Cheng, Mary Archer and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. What's New in Musculoskeletal Basic Science.The Journal of bone and joint surgery. American volume · 2025
    Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yiyun WangDepartment of Pathology, Johns Hopkins University, Baltimore, MD 21205, USA.
Neelima ThottappillilDepartment of Pathology, Johns Hopkins University, Baltimore, MD 21205, USA.
Mario Gomez-SalazarDepartment of Pathology, Johns Hopkins University, Baltimore, MD 21205, USA.
Robert J TowerDepartment of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Qizhi QinDepartment of Pathology, Johns Hopkins University, Baltimore, MD 21205, USA.
Ishbel Camila Del Rosario AlviaDepartment of Pathology, Johns Hopkins University, Baltimore, MD 21205, USA.
Mingxin XuDepartment of Pathology, Johns Hopkins University, Baltimore, MD 21205, USA.
Masnsen CheriefDepartment of Pathology, Johns Hopkins University, Baltimore, MD 21205, USA.
Ray ChengDepartment of Pathology, Johns Hopkins University, Baltimore, MD 21205, USA.
Mary ArcherDepartment of Pathology, Johns Hopkins University, Baltimore, MD 21205, USA.
Shreya ArondekarDepartment of Pathology, Johns Hopkins University, Baltimore, MD 21205, USA.
Sashank ReddyDepartment of Plastic and Reconstructive Surgery, Johns Hopkins University, Baltimore, MD 21205, USA.
Kristen BroderickDepartment of Plastic and Reconstructive Surgery, Johns Hopkins University, Baltimore, MD 21205, USA.
Bruno PéaultDepartment of Orthopedic Surgery and Orthopedic Hospital Research Center, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Aaron W JamesDepartment of Pathology, Johns Hopkins University, Baltimore, MD 21205, USA. Electronic address: awjames@jhmi.edu.

Funding

Skeleton and Joint Degeneration with AgingP01AG066603 · NIA · JOHNS HOPKINS UNIVERSITY · PI CAO, XU · 2021 to 2025
$9.2M
Impact of peripheral nerves on mesenchymal cell fate in extremity traumaR01AR079171 · NIAMS · UT SOUTHWESTERN MEDICAL CENTER · PI JAMES, AARON W, LEVI, BENJAMIN · 2021 to 2024
$3.0M
Biostimulatory nanofiber-hydrogel composite for soft tissue remodelingR01DE031488 · NIDCR · JOHNS HOPKINS UNIVERSITY · PI AARON W JAMES, Hai-Quan Mao · 2022 to 2026
$2.8M
Neuronal Regulation of Skeletal Development and RepairR01DE031028 · NIDCR · UNIVERSITY OF MARYLAND BALTIMORE · PI CLEMENS, THOMAS L, JAMES, AARON W · 2021 to 2025
$2.3M
Defining the human adventitial stem cell nicheR21AR078919 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI JAMES, AARON W, PEAULT, BRUNO M · 2022 to 2023
$404k
NIAMS NIH HHS R01 AR079171NIAMS NIH HHS R21 AR078919NIA NIH HHS P01 AG066603NIDCR NIH HHS R01 DE031028NIDCR NIH HHS R01 DE031488
6 · The paper itself

Abstract

Human blood vessel walls show concentric layers, with the outermost tunica adventitia harboring mesenchymal progenitor cells. These progenitor cells maintain vessel homeostasis and provide a robust cell source for cell-based therapies. However, human adventitial stem cell niche has not been studied in detail. Here, using spatial and single-cell transcriptomics, we characterized the phenotype, potential, and microanatomic distribution of human perivascular progenitors. Initially, spatial transcriptomics identified heterogeneity between perivascular layers of arteries and veins and delineated the tunica adventitia into inner and outer layers. From this spatial atlas, we inferred a hierarchy of mesenchymal progenitors dictated by a more primitive cell with a high surface expression of CD201 (PROCR). When isolated from humans and mice, CD201

Indexed as

Blood VesselsMesenchymal Stem CellsStem Cell NicheTranscriptomeAdventitiaAnimalsCell DifferentiationCell ProliferationHumansMiceOsteogenesisWnt Signaling Pathwayblood vesselmesenchymal stem/progenitor cellsossicle formationperivascularspatial transcriptomicsstem cell nichetunica adventitia

Identifiers

PMID39025061
PMCPMC11496018

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.