Evidence map›Paper›PMID 39026022›Full record

SynthesisArchives of gynecology and obstetrics2024

Combined oral contraceptive use and obesity in women with polycystic ovary syndrome. A meta-analysis of randomized clinical trials.

Sebastião Freitas de Medeiros, José Maria Soares Junior, Matheus Antonio Souto de Medeiros, Ana Karine Lin Winck Yamamoto, Cindy Lin Winck de Medeiros, Anna Bethany da Silva Carvalho, Márcia Marly Winck Yamamoto, Edmund Chada Baracat

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Archives of gynecology and obstetrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Observational
  6. Article
  7. PCOS and Obesity: Contraception Challenges.Open access journal of contraception · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sebastião Freitas de MedeirosDepartment of Gynecology and Obstetrics, Medical School, Federal University of Mato Grosso, Cuiabá, MT, Zip code 78 043 306, Brazil. de.medeiros@terra.com.br.ORCID http://orcid.org/0000-0003-1292-2515
José Maria Soares JuniorDisciplina de Ginecologia, University of São Paulo, São Paulo, Brazil.
Matheus Antonio Souto de MedeirosTropical Institute of Reproductive Medicine, Cuiabá, MT, Brazil.
Ana Karine Lin Winck YamamotoTropical Institute of Reproductive Medicine, Cuiabá, MT, Brazil.
Cindy Lin Winck de MedeirosUniversity of Cuiabá, Cuiabá, MT, Brazil.
Anna Bethany da Silva CarvalhoTropical Institute of Reproductive Medicine, Cuiabá, MT, Brazil.
Márcia Marly Winck YamamotoTropical Institute of Reproductive Medicine, Cuiabá, MT, Brazil.
Edmund Chada BaracatDisciplina de Ginecologia, University of São Paulo, São Paulo, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPolycystic ovary syndrome (PCOS) is a heterogenous endocrine condition and combined oral contraceptives (COCs) have been demonstrated to be the first-line treatment to women who do not intend to become pregnant. The combination of COCs and PCOS may or may not amplify the risks of cardiovascular events.

objectiveTo investigate whether surrogates for obesity may be influenced by the use of COCs containing different formulations in women with PCOS.

methodFrom January 2024 a literature search was conducted in Google Scholar and Pubmed databases using PCOS, COC, and obesity terms. Hand search of randomized clinical trials in the references of obtained manuscripts was also performed. After the exclusion of reviews and articles that did not fulfill eligibility criteria, compared the results obtained before and after the use of COCs in 13 randomized clinical trials (RCTs). Random-effects model was used to estimate the standardized mean differences (SMD) and standard errors (SE). Risk of bias was examined using the Rob2 tool.

resultThirteen heterogeneous RCTs reported no difference in waist circumference with the use of different COC formulations (p = 0.714). On the contrary, body fat mass increased with the use of pill (p = 0.013). Waist triglyceride index and lipid accumulation product tended to be higher after the use of COCs (p = 0.073 and p = 0.064, respectively).

conclusionCombined oral contraceptives with different formulations might increase fat mass accumulation in women with PCOS. Lipids may also be increased in PCOS users. Because some concerns about the quality and heterogeneity identified in various RCTs, caution should be taken before a definitive conclusion regarding the use of COCs and obesity.

Indexed as

Contraceptives, Oral, CombinedObesityPolycystic Ovary SyndromeFemaleHumansRandomized Controlled Trials as TopicWaist CircumferenceContraceptives, Oral, CombinedAdiposityBiomarkersLipidsMetabolismOral contraceptivePolycystic ovary syndrome

Identifiers

PMID39026022

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.