Evidence map›Paper›PMID 39026677›Full record

ReviewFrontiers in immunology2024

Hem1 inborn errors of immunity: waving goodbye to coordinated immunity in mice and humans.

Alexandra Christodoulou, Julia Y Tsai, Nutthakarn Suwankitwat, Andreas Anderson, Brian M Iritani

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alexandra ChristodoulouThe Department of Comparative Medicine, University of Washington, Seattle, WA, United States.
Julia Y TsaiThe Department of Comparative Medicine, University of Washington, Seattle, WA, United States.
Nutthakarn SuwankitwatThe Department of Comparative Medicine, University of Washington, Seattle, WA, United States.
Andreas AndersonThe Department of Comparative Medicine, University of Washington, Seattle, WA, United States.
Brian M IritaniThe Department of Comparative Medicine, University of Washington, Seattle, WA, United States.

Funding

WAVE Regulatory Complex in Primary Immunodeficiency Disease and autoimmunityR01AI158353 · NIAID · UNIVERSITY OF WASHINGTON · PI IRITANI, BRIAN M · 2021 to 2025
$2.8M
Dissecting Hem-1 functions in B lymphocyte Development and Primary Immunodeficiency DiseaseR21AI156243 · NIAID · UNIVERSITY OF WASHINGTON · PI IRITANI, BRIAN M · 2021 to 2022
$428k
NIAID NIH HHS R01 AI158353NIAID NIH HHS R21 AI156243
6 · The paper itself

Abstract

Inborn errors of immunity (IEI) are a group of diseases in humans that typically present as increased susceptibility to infections, autoimmunity, hyperinflammation, allergy, and in some cases malignancy. Among newly identified genes linked to IEIs include 3 independent reports of 9 individuals from 7 independent kindreds with severe primary immunodeficiency disease (PID) and autoimmunity due to loss-of-function mutations in the

Indexed as

Immunologic Deficiency SyndromesAnimalsHumansMiceactin cytoskeletonHem-1Hem1hematopoietic protein-1immunodeficiency diseaseinborn errors of immunityNCKAP1Lwave

Identifiers

PMID39026677
PMCPMC11254771

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.