Evidence map›Paper›PMID 39026725›Full record

ArticlebioRxiv : the preprint server for biology2025

Antagonistic Roles for MITF and TFE3 in Melanoma Plasticity.

Jeremy Chang, Katelyn R Campbell-Hanson, Marion Vanneste, Nicholas I Bartschat, Ryan Nagel, Asdis K Arnadottir, Hong Nhung Vu, Collin Montgomery, Julius Yevdash, Jiarui Jiang and 7 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Jeremy ChangDepartment of Surgery, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Katelyn R Campbell-HansonDepartment of Surgery, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Marion VannesteDepartment of Molecular Physiology and Biophysics, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Nicholas I BartschatDepartment of Surgery, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.ORCID 0000-0003-4513-358X
Ryan NagelDepartment of Surgery, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Asdis K ArnadottirDepartment of Biochemistry and Molecular Biology, BioMedical Center, Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Hong Nhung VuDepartment of Biochemistry and Molecular Biology, BioMedical Center, Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Collin MontgomeryDepartment of Surgery, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Julius YevdashDepartment of Surgery, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Jiarui JiangDepartment of Surgery, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Ardith BhinuDepartment of Surgery, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Annika HelversonDepartment of Biostatistics, College of Public Health, University of Iowa, Iowa City, IA, USA.
Michael D HenryDepartment of Molecular Physiology and Biophysics, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.ORCID 0000-0002-7871-245X
Eiríkur SteingrímssonDepartment of Biochemistry and Molecular Biology, BioMedical Center, Faculty of Medicine, University of Iceland, Reykjavik, Iceland.ORCID 0000-0001-5826-7486
Ronald J WeigelDepartment of Surgery, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Robert A CornellDepartment of Oral Health Sciences, University of Washington, School of Dentistry, Seattle, WA, USA.
Colin KennyDepartment of Surgery, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.ORCID 0000-0001-8926-4413

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Jon C.D. Houtman · 2000 to 2026
$70.0M
NCI NIH HHS P30 CA086862
6 · The paper itself

Abstract

Melanoma cells have the ability to switch from a melanocytic and proliferative state to a mesenchymal and invasive state and back again. This plasticity drives intra-tumoral heterogeneity, progression, and therapeutic resistance. Microphthalmia-associated Transcription Factor (MITF) promotes the melanocytic/proliferative phenotype, but factors that drive the mesenchymal/invasive phenotype and the mechanisms that effect the switch between cell states are unclear. Here, we identify the MITF paralog TFE3 and the non-canonical mTORC1 pathway as regulators of the mesenchymal state. We show that TFE3 expression drives the metastatic phenotype in melanoma cell lines and tumors. Deletion of TFE3 in MITF-low melanoma cell lines suppresses their ability to migrate and metastasize. Further, MITF suppresses the mesenchymal phenotype by directly or indirectly activating expression of

Indexed as

cell plasticityMelanomametastasisMITFmTORC1phenotype-switchingprotein stabilityTFE3

Identifiers

PMID39026725
PMCPMC11257520

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.