Evidence map›Paper›PMID 39026749›Full record

ArticlebioRxiv : the preprint server for biology2024

Spleen Tyrosine Kinase (SYK) negatively regulates ITAM-mediated human NK cell signaling and CD19-CAR NK cell efficacy.

Alberto J Millan, Vincent Allain, Indrani Nayak, Oscar A Aguilar, Janice S Arakawa-Hoyt, Gabriella Ureno, Allison Grace Rothrock, Avishai Shemesh, Justin Eyquem, Jayajit Das and 1 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Alberto J MillanDepartment of Microbiology and Immunology and the Parker Institute for Cancer Immunotherapy, University of California-San Francisco, San Francisco, CA, USA.ORCID 0000-0003-1186-7219
Vincent AllainDepartment of Medicine, University of California-San Francisco, San Francisco, CA, USA.ORCID 0000-0002-1068-7892
Indrani NayakSteve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children's Hospital, Biomedical Sciences Graduate Program, Department of Pediatrics, Pelotonia Institute for Immuno-Oncology, College of Medicine, The Ohio State University, Columbus OH.ORCID 0000-0002-4257-8965
Oscar A AguilarDepartment of Microbiology and Immunology and the Parker Institute for Cancer Immunotherapy, University of California-San Francisco, San Francisco, CA, USA.ORCID 0000-0002-7990-8745
Janice S Arakawa-HoytDepartment of Microbiology and Immunology and the Parker Institute for Cancer Immunotherapy, University of California-San Francisco, San Francisco, CA, USA.ORCID 0000-0003-0969-1082
Gabriella UrenoDepartment of Microbiology and Immunology and the Parker Institute for Cancer Immunotherapy, University of California-San Francisco, San Francisco, CA, USA.
Allison Grace RothrockDepartment of Medicine, University of California-San Francisco, San Francisco, CA, USA.
Avishai ShemeshDepartment of Microbiology and Immunology and the Parker Institute for Cancer Immunotherapy, University of California-San Francisco, San Francisco, CA, USA.ORCID 0000-0002-6934-7155
Justin EyquemDepartment of Medicine, University of California-San Francisco, San Francisco, CA, USA.ORCID 0000-0001-8262-1190
Jayajit DasSteve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children's Hospital, Biomedical Sciences Graduate Program, Department of Pediatrics, Pelotonia Institute for Immuno-Oncology, College of Medicine, The Ohio State University, Columbus OH.ORCID 0000-0001-9649-4698
Lewis L LanierDepartment of Microbiology and Immunology and the Parker Institute for Cancer Immunotherapy, University of California-San Francisco, San Francisco, CA, USA.ORCID 0000-0003-1308-3952

Funding

Mechanistic Modeling of Cellular SystemsR24GM137787 · NIGMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI Pedro Mendes, Ion I. Moraru · 2020 to 2026
$8.9M
Modeling Antibody-induced Immune Responses by NK cells in Mice and Humans (Resubmission 1)R01AI146581 · NIAID · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI DAS, JAYAJIT · 2020 to 2025
$2.3M
NIAID NIH HHS R01 AI146581NIGMS NIH HHS R24 GM137787
6 · The paper itself

Abstract

NK cells express activating receptors that signal through ITAM-bearing adapter proteins. The phosphorylation of each ITAM creates binding sites for SYK and ZAP70 protein tyrosine kinases to propagate downstream signaling including the induction of

Indexed as

Cell ActivationCell Surface MoleculesFc receptorsHumanNatural killer cellsT cells

Identifiers

PMID39026749
PMCPMC11257556

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.