ArticlebioRxiv : the preprint server for biology2024
Cerebellar output neurons impair non-motor behaviors by altering development of extracerebellar connectivity.
Andrew S Lee, Tanzil M Arefin, Alina Gubanova, Daniel N Stephen, Yu Liu, Zhimin Lao, Anjana Krishnamurthy, Natalia V De Marco García, Detlef H Heck, Jiangyang Zhang and 2 more
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
12 authors.
Tanzil M ArefinBernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York 10016, NY, USA.ORCID 0000-0002-4876-7548 Alina GubanovaDevelopmental Biology Program, Sloan Kettering Institute, New York 10065, NY, USA.
Daniel N StephenDevelopmental Biology Program, Sloan Kettering Institute, New York 10065, NY, USA.
Yu LiuDepartment of Biomedical Sciences, University of Minnesota Medical School, Duluth, MN 55812, USA.
Zhimin LaoDevelopmental Biology Program, Sloan Kettering Institute, New York 10065, NY, USA.
Anjana KrishnamurthyDevelopmental Biology Program, Sloan Kettering Institute, New York 10065, NY, USA.
Natalia V De Marco GarcíaNeuroscience Program, Weill Cornell Graduate School of Medical Sciences, New York 10021, NY, USA.
Detlef H HeckDepartment of Biomedical Sciences, University of Minnesota Medical School, Duluth, MN 55812, USA.
Jiangyang ZhangBernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York 10016, NY, USA.ORCID 0000-0003-0740-2662 Anjali M RajadhyakshaNeuroscience Program, Weill Cornell Graduate School of Medical Sciences, New York 10021, NY, USA.
Alexandra L JoynerDevelopmental Biology Program, Sloan Kettering Institute, New York 10065, NY, USA.ORCID 0000-0001-7090-9605 Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4MEngrailed genes and cerebellum morphology, spatial gene expression and circuitryR37MH085726 · NIMH · SLOAN-KETTERING INST CAN RESEARCH · PI JOYNER, ALEXANDRA L. · 2014 to 2023
$6.7MJ. NRSA Training CoreTL1TR002386 · NCATS · WEILL MEDICAL COLL OF CORNELL UNIV · PI Genevieve Giny Fouda Amou ou · 2017 to 2026
$5.8MSignaling Pathways that Regulate Scaling and Regeneration of the CerebellumR01NS092096 · NINDS · SLOAN-KETTERING INST CAN RESEARCH · PI JOYNER, ALEXANDRA L. · 2015 to 2024
$4.8MNeural Mechanism for the assembly of GABAergic in the cerebral cortexR01MH110553 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI Natalia Vanesa De Marco Garcia · 2016 to 2026
$4.2MTraining Program in Developmental BiologyT32HD060600 · NICHD · WEILL MEDICAL COLL OF CORNELL UNIV · PI BAO, ZHIRONG, STUHLMANN, HEIDI · 2010 to 2024
$3.5MCircuit and Synaptic Mechanisms of Endocannabinoid-Opioid CrosstalkR01DA054368 · NIDA · WEILL MEDICAL COLL OF CORNELL UNIV · PI Francis Sang Yong Lee, Anjali M Rajadhyaksha · 2022 to 2026
$3.5MMolecular and circuit defects underlying different SCN2A mutations and ASDsR01MH118934 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI PITT, GEOFFREY S · 2019 to 2023
$3.2MQuantitative Imaging of Mouse Brain DevelopmentR01NS102904 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ZHANG, JIANGYANG · 2018 to 2022
$3.1MInvestigating the mechanistic contribution of Cav1.2 channels in extinction of cocaine-associated memoriesR01DA053261 · NIDA · WEILL MEDICAL COLL OF CORNELL UNIV · PI Anjali M Rajadhyaksha · 2022 to 2026
$2.6MA Circuit Mechanism for the Development of Cortico-cortical ConnectivityR01NS116137 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI DE MARCO GARCIA, NATALIA VANESA · 2020 to 2024
$2.6MNeuronal mechanisms of cerebellar cognitive functionR01MH112143 · NIMH · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI HECK, DETLEF H · 2018 to 2022
$2.3MNCATS NIH HHS TL1 TR002386NCI NIH HHS P30 CA008748NICHD NIH HHS T32 HD060600NIDA NIH HHS R01 DA029122NIDA NIH HHS R01 DA050454NIDA NIH HHS R01 DA053261NIDA NIH HHS R01 DA054368NIMH NIH HHS R01 MH110553NIMH NIH HHS R01 MH112143NIMH NIH HHS R01 MH118934NIMH NIH HHS R01 MH125006NIMH NIH HHS R37 MH085726NINDS NIH HHS R01 NS092096NINDS NIH HHS R01 NS102904NINDS NIH HHS R01 NS116137
6 · The paper itselfAbstract
The capacity of the brain to compensate for insults during development depends on the type of cell loss, whereas the consequences of genetic mutations in the same neurons are difficult to predict. We reveal powerful compensation from outside the cerebellum when the excitatory cerebellar output neurons are ablated embryonically and demonstrate that the minimum requirement for these neurons is for motor coordination and not learning and social behaviors. In contrast, loss of the homeobox transcription factors Engrailed1/2 (EN1/2) in the cerebellar excitatory lineage leads to additional deficits in adult learning and spatial working memory, despite half of the excitatory output neurons being intact. Diffusion MRI indicates increased thalamo-cortico-striatal connectivity in
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PMID39026865
PMCPMC11257463
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