Evidence map›Paper›PMID 39028811›Full record

ArticleScience advances2024

Small-molecule probe for IBD risk variant GPR65 I231L alters cytokine signaling networks through positive allosteric modulation.

Ilona Neale, Clark Reddy, Zher Yin Tan, Bihua Li, Partha P Nag, Joshua Park, Jihye Park, Kimberly L Carey, Daniel B Graham, Ramnik J Xavier

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ilona NealeBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0009-0006-3393-9702
Clark ReddyBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0009-0008-5454-8035
Zher Yin TanBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0003-2498-043X
Bihua LiBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Partha P NagBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Joshua ParkBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0009-0008-8969-3638
Jihye ParkBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0003-4796-0028
Kimberly L CareyBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0002-0836-8710
Daniel B GrahamBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0002-8403-8115
Ramnik J XavierBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0002-5630-5167

Funding

Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Ramnik J Xavier · 1991 to 2026
$35.3M
Genetic and Pathway Analysis CoreU19AI109725 · NIAID · WASHINGTON UNIVERSITY · PI ALLEN, PAUL M · 2014 to 2018
$32.7M
Lysosome Homeostasis and Microbicidal Mechanisms in Innate ImmunityR01DK117263 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI XAVIER, RAMNIK J · 2018 to 2021
$2.4M
NIAID NIH HHS U19 AI109725NIDDK NIH HHS P30 DK043351NIDDK NIH HHS R01 DK117263
6 · The paper itself

Abstract

The proton-sensing heterotrimeric guanine nucleotide-binding protein-coupled receptor GPR65 is expressed in immune cells and regulates tissue homeostasis in response to decreased extracellular pH, which occurs in the context of inflammation and tumorigenesis. Genome-wide association studies linked

Indexed as

CytokinesInflammatory Bowel DiseasesReceptors, G-Protein-CoupledSignal TransductionAllosteric RegulationAnimalsDendritic CellsHumansMiceMolecular ProbesCytokinesGPR65 protein, humanMolecular ProbesReceptors, G-Protein-Coupled

Identifiers

PMID39028811
PMCPMC11259170

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.