Evidence mapPaperPMID 39030405Full record

ReviewNature medicine2024

Reporting guidelines for precision medicine research of clinical relevance: the BePRECISE checklist.

Siew S Lim, Zhila Semnani-Azad, Mario L Morieri, Ashley H Ng, Abrar Ahmad, Hugo Fitipaldi, Jacqueline Boyle, Christian Collin, John M Dennis, Claudia Langenberg and 13 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Association of genetic risk and physical activity with incident type 2 diabetes.The Journal of clinical endocrinology and metabolism · 2026
    Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Precision medicine in cutaneous melanoma-A comprehensive review.Journal of the European Academy of Dermatology and Venereology : JEADV · 2026
    Review
  9. GLP-1 receptor agonists or SGLT2-inhibitors? Evaluation of a personalized treatment algorithm for individuals with type 2 diabetes: a registry-based cohort study.Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association · 2026
    Observational
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Observational
  17. Review
  18. Diagnostic yield in families to sudden cardiac death victims: a 10-year follow-up study.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Siew S LimHealth Systems and Equity, Eastern Health Clinical School, Monash University, Box Hill, Victoria, Australia.
Zhila Semnani-AzadDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.ORCID 0000-0001-7822-5072
Mario L MorieriUnit of Metabolic Disease, University-Hospital of Padua, Padua, Italy.ORCID 0000-0001-6864-0547
Ashley H NgMonash Centre for Health Research Implementation, Monash University and Monash Health, Melbourne, Victoria, Australia.
Abrar AhmadDiabetic Complications Unit, Department of Clinical Sciences, Lund University Diabetes Centre, Malmo, Sweden.
Hugo FitipaldiDiabetic Complications Unit, Department of Clinical Sciences, Lund University Diabetes Centre, Malmo, Sweden.
Jacqueline BoyleHealth Systems and Equity, Eastern Health Clinical School, Monash University, Box Hill, Victoria, Australia.
Christian CollinBoard of Directors, Steno Diabetes Center, Copenhagen, Denmark.
John M DennisDepartment of Clinical and Biomedical Sciences, University of Exeter Medical School, Exeter, UK.ORCID 0000-0002-7171-732X
Claudia LangenbergPrecision Healthcare University Research Institute, Queen Mary University of London, London, UK.ORCID 0000-0002-5017-7344
Ruth J F LoosNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Melinda MorrisonDiabetes Australia, Canberra, Australian Capital Territory, Australia.
Michele RamsaySydney Brenner Institute for Molecular Bioscience, University of the Witwatersrand, Faculty of Health Sciences, Johannesburg, South Africa.ORCID 0000-0002-4156-4801
Arun J SanyalDivision of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.ORCID 0000-0001-8682-5748
Naveed SattarSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.ORCID 0000-0002-1604-2593
Marie-France HivertDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute; Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0001-7752-2585
Maria F GomezDiabetic Complications Unit, Department of Clinical Sciences, Lund University Diabetes Centre, Malmo, Sweden.ORCID 0000-0001-6210-3142
Jordi MerinoNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-8312-1438
Deirdre K TobiasDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Michael I TrenellPopulation Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Stephen S RichCenter for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.ORCID 0000-0003-3872-7793
Jennifer L SargentSchool of Public Health, Imperial College London, London, UK.
Paul W FranksDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA. paul.franks@med.lu.se.ORCID 0000-0002-0520-7604

Funding

Breakthrough T1D 2-SRA-202201260-S-BInnovative Medicines Initiative (IMI) 115974 - BEAt-DKDNIDDK NIH HHS R01 DK122586Novo Nordisk Fonden (Novo Nordisk Foundation) NNF23SA0084103, NNF18CC0034900, NNF20OC0059313RCUK | Medical Research Council (MRC) MR/N00633X/1Stiftelsen för Strategisk Forskning (Swedish Foundation for Strategic Research) LUDC-IRC, 15-0067Vetenskapsrådet (Swedish Research Council) 2018-02837Vetenskapsrådet (Swedish Research Council) #2019-01348Wellcome Trust 227070/Z/23/Z
6 · The paper itself

Abstract

Precision medicine should aspire to reduce error and improve accuracy in medical and health recommendations by comparison with contemporary practice, while maintaining safety and cost-effectiveness. The etiology, clinical manifestation and prognosis of diseases such as obesity, diabetes, cardiovascular disease, kidney disease and fatty liver disease are heterogeneous. Without standardized reporting, this heterogeneity, combined with the diversity of research tools used in precision medicine studies, makes comparisons across studies and implementation of the findings challenging. Specific recommendations for reporting precision medicine research do not currently exist. The BePRECISE (Better Precision-data Reporting of Evidence from Clinical Intervention Studies & Epidemiology) consortium, comprising 23 experts in precision medicine, cardiometabolic diseases, statistics, editorial and lived experience, conducted a scoping review and participated in a modified Delphi and nominal group technique process to develop guidelines for reporting precision medicine research. The BePRECISE checklist comprises 23 items organized into 5 sections that align with typical sections of a scientific publication. A specific section about health equity serves to encourage precision medicine research to be inclusive of individuals and communities that are traditionally under-represented in clinical research and/or underserved by health systems. Adoption of BePRECISE by investigators, reviewers and editors will facilitate and accelerate equitable clinical implementation of precision medicine.

Indexed as

ChecklistPrecision MedicineBiomedical ResearchClinical RelevanceGuidelines as TopicHumansResearch Design

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.