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ArticleActa biochimica et biophysica Sinica2024

ZIPK collaborates with STAT5A in p53-mediated ROS accumulation in hyperglycemia-induced vascular injury.

Qichao Wu, Tingting Xie, Chang Fu, Chenyu Sun, Yan Ma, Zhengzhe Huang, Jiao Yang, Xiaoxiao Li, Wenqian Li, Changhong Miao

Abstract read
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In one paragraph

Article in Acta biochimica et biophysica Sinica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Qichao WuDepartment of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai 200031, China.
Tingting XieDepartment of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai 200031, China.
Chang FuDepartment of Anesthesiology, Fudan University Shanghai Cancer Center, Shanghai 200031, China.
Chenyu SunDepartment of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai 200031, China.
Yan MaDepartment of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai 200031, China.
Zhengzhe HuangDepartment of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai 200031, China.
Jiao YangDepartment of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai 200031, China.
Xiaoxiao LiDepartment of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai 200031, China.
Wenqian LiDepartment of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai 200031, China.
Changhong MiaoDepartment of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai 200031, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study we investigate the role of Zipper-interacting protein kinase (ZIPK) in high glucose-induced vascular injury, focusing on its interaction with STAT5A and its effects on p53 and inducible nitric oxide synthase (NOS2) expression. Human umbilical vein endothelial cells (HUVECs) are cultured under normal (5 mM) and high (25 mM) glucose conditions. Protein and gene expression levels are assessed by western blot analysis and qPCR respectively, while ROS levels are measured via flow cytometry. ZIPK expression is manipulated using overexpression plasmids, siRNAs, and shRNAs. The effects of the ZIPK inhibitor TC-DAPK6 are evaluated in a diabetic rat model. Our results show that high glucose significantly upregulates ZIPK, STAT5A, p53, and NOS2 expressions in HUVECs, thus increasing oxidative stress. Silencing of

Indexed as

HyperglycemiaReactive Oxygen SpeciesSTAT5 Transcription FactorTumor Suppressor Protein p53Vascular System InjuriesAnimalsDiabetes Mellitus, ExperimentalGlucoseHumansHuman Umbilical Vein Endothelial CellsMaleNitric Oxide Synthase Type IIOxidative StressRatsRats, Sprague-DawleyTumor Suppressor ProteinsGlucoseNitric Oxide Synthase Type IIReactive Oxygen SpeciesSTAT5A protein, humanSTAT5 Transcription FactorTumor Suppressor Protein p53Tumor Suppressor Proteinsp53ROS accumulationSTAT5AZIPK

Identifiers

PMID39030705
PMCPMC11986451

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.