Evidence map›Paper›PMID 39031245›Full record

ArticleSleep & breathing = Schlaf & Atmung2024

Crosstalk between gastrointestinal tract disorders and obstructive sleep apnea.

Shijie Jian, Jie Liu, Meng He, Bin Liu, Kun Liu, Chenyang Zang, Xiaoli Su, Yuan Zhang, Minhan Yi

Abstract read
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In one paragraph

Article in Sleep & breathing = Schlaf & Atmung, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shijie Jian *Department of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, China.
Jie Liu *Department of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, China.
Meng HeDepartment of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, China.
Bin LiuDepartment of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, China.
Kun LiuSchool of Life Sciences, Central South University, Changsha, China.
Chenyang ZangXiangya Medical School, Central South University, Changsha, China.
Xiaoli SuDepartment of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, China. suli8779@163.com.
Yuan ZhangDepartment of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, China. zhangyuan9194@csu.edu.cn.
Minhan YiSchool of Life Sciences, Central South University, Changsha, China. minhan@csu.edu.cn.ORCID 0000-0001-6816-8115

Funding

Natural Science Foundation of Hunan Province No.2024JJ8133, No.2023JJ20098
6 · The paper itself

Abstract

purposeClinical studies suggested associations between obstructive sleep apnea (OSA) and gastrointestinal tract disorders. This study aims to investigate the genetic causal relationship between OSA and gastrointestinal tract disorders, specifically gastroesophageal reflux disease (GERD) and inflammatory bowel disease (IBD).

methodsIn this study, we employed two-sample Mendelian Randomization (MR) analysis to investigate the potential relationships between OSA and GERD, and between OSA and IBD. More specifically, the primary analysis utilized inverse variance weighting (IVW). Weighted median, MR Egger, and MR PRESSO were applied to complicate potential violations of MR assumptions. Also, sensitivity analysis was evaluated and similar analysis was performed again after outliers were removed. Additionally, multivariable MR (MVMR) was conducted for associated pairs to adjust for obesity.

resultsGenetically predicted risk of GERD increased OSA risk by approximately 60% (OR

conclusionGERD exerts a substantial causality on increasing the risk of OSA. Conversely, the potential for a causal relationship that OSA contributes to the development of GERD or IBD remains probable. These findings support the crosstalk between gastrointestinal tract disorders and OSA.

Indexed as

Gastroesophageal RefluxMendelian Randomization AnalysisSleep Apnea, ObstructiveGastrointestinal DiseasesHumansInflammatory Bowel DiseasesObesityCausalityGastroesophageal reflux diseaseInflammatory bowel diseaseObstructive sleep apnea

Identifiers

PMID39031245

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.