Evidence map›Paper›PMID 39031532›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2024

Loss of Calpain 3 dysregulates store-operated calcium entry and its exercise response in mice.

Katelyn R Villani, Renjia Zhong, C Spencer Henley-Beasley, Giorgia Rastelli, Erin Harris, Simona Boncompagni, Elisabeth R Barton, Lan Wei-LaPierre

Abstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Katelyn R VillaniDepartment of Applied Physiology and Kinesiology, College of Health and Human Performance, University of Florida, Gainesville, Florida, USA.ORCID 0009-0008-3274-0923
Renjia ZhongDepartment of Applied Physiology and Kinesiology, College of Health and Human Performance, University of Florida, Gainesville, Florida, USA.ORCID 0000-0003-4448-6551
C Spencer Henley-BeasleyDepartment of Applied Physiology and Kinesiology, College of Health and Human Performance, University of Florida, Gainesville, Florida, USA.ORCID 0009-0005-3839-6332
Giorgia RastelliCenter for Advanced Studies and Technology, University G. d'Annunzio of Chieti-Pescara, Chieti, Italy.ORCID 0000-0002-2476-7519
Erin HarrisDepartment of Applied Physiology and Kinesiology, College of Health and Human Performance, University of Florida, Gainesville, Florida, USA.ORCID 0009-0006-0370-2675
Simona BoncompagniCenter for Advanced Studies and Technology, University G. d'Annunzio of Chieti-Pescara, Chieti, Italy.ORCID 0000-0001-5308-5069
Elisabeth R BartonDepartment of Applied Physiology and Kinesiology, College of Health and Human Performance, University of Florida, Gainesville, Florida, USA.ORCID 0000-0002-7401-4398
Lan Wei-LaPierreDepartment of Applied Physiology and Kinesiology, College of Health and Human Performance, University of Florida, Gainesville, Florida, USA.ORCID 0000-0002-4781-5886

Funding

Understanding and Improving Therapies for the Muscular Dystrophies through Noninvasive BiomarkersP50AR052646 · NIAMS · UNIVERSITY OF FLORIDA · PI SWEENEY, H LEE · 2021 to 2024
$6.2M
Coalition to Cure Calpain 3 Foundation AGR00024098NIAMS NIH HHS P50 AR052646
6 · The paper itself

Abstract

Limb-Girdle Muscular Dystrophy R1/2A (LGMD R1/2A) is caused by mutations in the CAPN3 gene encoding Calpain 3, a skeletal-muscle specific, Ca

Indexed as

CalciumCalpainMice, KnockoutMuscle ProteinsMuscle, SkeletalPhysical Conditioning, AnimalAnimalsCalcium SignalingMaleMiceMice, Inbred C57BLMuscular Dystrophies, Limb-GirdleCalciumCalpainCapn3 protein, mouseMuscle Proteinscalcium homeostasisLimb Girdle Muscular Dystrophy R1/2AORAI1skeletal muscleSTIM1

Identifiers

PMID39031532
PMCPMC11299996

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.