Evidence map›Paper›PMID 39033277›Full record

ArticleAllergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology2024

Role of Th2, Th17 and Treg Cells and relevant cytokines in pathogenesis of allergic rhinitis.

Li-Ping Guo, Min Yan, Rui-Bing Niu, Lei Liu, Jing-Ru Yang, Rui-Lian Chen, Bao-Sheng Duan, Cui-Cui Li, Jian-Xiong Li

Abstract read
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In one paragraph

Article in Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Li-Ping Guo *Department of Dermatology, Ordos Central Hospital, Ordos, 017000, Inner Mongolia, China.
Min Yan *Department of Clinical Laboratory, Ordos Central Hospital, No. 23, Ejinholo West Street, Dongsheng District, Ordos, 017000, Inner Mongolia, China.
Rui-Bing NiuDepartment of Clinical Laboratory, Ordos Central Hospital, No. 23, Ejinholo West Street, Dongsheng District, Ordos, 017000, Inner Mongolia, China. niubing_rr@163.com.
Lei LiuDepartment of Otolaryngology, Ordos Central Hospital, Ordos, 017000, Inner Mongolia, China.
Jing-Ru YangDepartment of Otolaryngology, Ordos Central Hospital, Ordos, 017000, Inner Mongolia, China.
Rui-Lian ChenDepartment of Otolaryngology, Ordos Central Hospital, Ordos, 017000, Inner Mongolia, China.
Bao-Sheng DuanDepartment of Clinical Laboratory, Ordos Central Hospital, No. 23, Ejinholo West Street, Dongsheng District, Ordos, 017000, Inner Mongolia, China.
Cui-Cui LiDepartment of Clinical Laboratory, Ordos Central Hospital, No. 23, Ejinholo West Street, Dongsheng District, Ordos, 017000, Inner Mongolia, China.
Jian-Xiong LiDepartment of Clinical Laboratory, Ordos Central Hospital, No. 23, Ejinholo West Street, Dongsheng District, Ordos, 017000, Inner Mongolia, China.

Funding

Hygiene and Health Science and Technology Plan Project of Inner Mongolia Autonomous Region 202201587Science and Technology Plan Project of Ordos 2021YY She 184-59
6 · The paper itself

Abstract

objectiveTo explore the role of different cells and molecules in the pathogenesis of allergic rhinitis (AR) with positive Artemisia allergen by detecting their expression levels.

methodsFrom January 2021 to December 2022,200 AR patients diagnosed in the Otolaryngology Clinic of Ordos Central Hospital were selected as the AR group, and 50 healthy people who underwent physical examination in the hospital during the same period were randomly selected as the healthy control (HC) group. The levels of GATA-3mRNA, RORγtmRNA and FoxP3mRNA in peripheral blood mononuclear cells were detected by real-time fluorescence quantitative PCR (qRT-PCR). The proportions of Th2, Th17 and Treg cells were detected by flow cytometry. The concentrations of IL-4, IL-5, IL-17 and IL-10 in serum were detected by enzyme-linked immunosorbent assay. The differences of transcription gene level, immune cell ratio and cytokine concentration between the two groups were analyzed.

resultsThere was no difference in age and gender between the two groups. The levels of GATA-3mRNA and RORγtmRNA transcription genes in peripheral blood mononuclear cells, the percentage of Th2, Th17 and Treg immune cells, the levels of eosinophils and basophils in peripheral blood, the concentrations of IL-4, IL-5, IL-17, IL-10 cytokines and IgE in serum of AR patients were significantly higher than those in HC group (P < 0.05). IL-4 and IL-17 were positively correlated with total IgE level.

conclusionThe secretion of immune cells and cytokines in peripheral blood of AR patients is abnormal. Th2, Th17, Treg specific transcription factors and related cells and cytokines are involved in the occurrence and development of allergic rhinitis.

Indexed as

Allergic rhinitisTh17Th2Treg

Identifiers

PMID39033277
PMCPMC11264892

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.