Evidence map›Paper›PMID 39033485›Full record

ArticleUpdates in surgery2024

Surgery for pancreatic neuroendocrine tumors during the COVID-19 pandemic: a retrospective cohort from a high-volume center.

Salvatore Paiella, Luca Landoni, Matteo De Pastena, Giovanni Elio, Fabio Casciani, Sara Cingarlini, Mirko D'Onofrio, Giulia Maistri, Ivan Ciatti, Massimiliano Tuveri and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Updates in surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Salvatore PaiellaPancreatic Surgery Unit, Pancreas Institute, University of Verona, Policlinico GB Rossi, Piazzale Scuro 10, 37134, Verona, Italy.ORCID http://orcid.org/0000-0001-6893-8618
Luca LandoniPancreatic Surgery Unit, Pancreas Institute, University of Verona, Policlinico GB Rossi, Piazzale Scuro 10, 37134, Verona, Italy.
Matteo De PastenaPancreatic Surgery Unit, Pancreas Institute, University of Verona, Policlinico GB Rossi, Piazzale Scuro 10, 37134, Verona, Italy.
Giovanni ElioPancreatic Surgery Unit, Pancreas Institute, University of Verona, Policlinico GB Rossi, Piazzale Scuro 10, 37134, Verona, Italy.
Fabio CascianiPancreatic Surgery Unit, Pancreas Institute, University of Verona, Policlinico GB Rossi, Piazzale Scuro 10, 37134, Verona, Italy.
Sara CingarliniOncology Unit, Pancreas Institute, University of Verona, Verona, Italy.
Mirko D'OnofrioRadiology Unit, Pancreas Institute, University of Verona, Verona, Italy.
Giulia MaistriPancreatic Surgery Unit, Pancreas Institute, University of Verona, Policlinico GB Rossi, Piazzale Scuro 10, 37134, Verona, Italy.
Ivan CiattiPancreatic Surgery Unit, Pancreas Institute, University of Verona, Policlinico GB Rossi, Piazzale Scuro 10, 37134, Verona, Italy.
Massimiliano TuveriPancreatic Surgery Unit, Pancreas Institute, University of Verona, Policlinico GB Rossi, Piazzale Scuro 10, 37134, Verona, Italy.
Maria Vittoria DavìDepartment of Medicine, Section of Endocrinology, University and Hospital Trust of Verona, Verona, Italy.
Claudio LuchiniDepartment of Diagnostics and Public Health, Section of Pathology, University of Verona, Verona, Italy.
Katia DonadelloAnaesthesia and Intensive Care Unit B, University of Verona Hospital Trust, Verona, Italy.
Gessica ManziniSurgical Block, University of Verona Hospital Trust, Verona, Italy.
Giuseppe MalleoPancreatic Surgery Unit, Pancreas Institute, University of Verona, Policlinico GB Rossi, Piazzale Scuro 10, 37134, Verona, Italy.
Roberto SalviaPancreatic Surgery Unit, Pancreas Institute, University of Verona, Policlinico GB Rossi, Piazzale Scuro 10, 37134, Verona, Italy. roberto.salvia@univr.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During the COVID-19 pandemic, pancreatic surgery for pancreatic neuroendocrine tumors (PNETs) with surgical indications was postponed or canceled. Patients with PNET patients who underwent pancreatic surgery during the COVID-19 restriction period (3 years) were compared with a similar cohort of patients who underwent surgery in the previous 3 years. Data on patients' characteristics, waiting time, and surgical and pathology outcomes were evaluated. During the study period, 370 patients received surgery for PNETs, 205 (55%) during the first period, and 165 (45%) during the pandemic. A lengthening of the waiting list (182 [IQR 100-357] vs. 60 [40-88] days, p < 0.001) and increased use of anti-tumor medical treatments (any therapy, peptide receptor radionuclide therapy, and somatostatin analogs; all p < 0.001) was found. During the pandemic, surgery occurred after a median of 381 days [IQR 200-610] from diagnosis (vs. 103 [IQR 52-192] of the pre-COVID-19 period, p < 0.001). No statistically significant differences in tumor size and grading distribution were found between the two periods (both p > 0.05), yet only a modest increase of the median Ki67 values in cases operated during the pandemic (4% vs. 3%, p = 0.03). Lastly, these latter patients experienced less major postoperative complications (13% vs. 24%, p = 0.007). During COVID-19, the surgical waiting list of PNET patients was drastically extended, and bridge therapies were preferred. This did not result in more advanced cases at final pathology. PRRT and SSA are valid alternative therapies for PNETs when surgery is not feasible.

Indexed as

COVID-19Hospitals, High-VolumeNeuroendocrine TumorsPancreatic NeoplasmsAgedCohort StudiesFemaleHumansMaleMiddle AgedPancreatectomyPandemicsRetrospective StudiesWaiting ListsCOVID-19Pancreatic neuroendocrine tumorsPancreatic surgeryPancreatic tumorsSARS-CoV2

Identifiers

PMID39033485
PMCPMC11455720

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.