Evidence map›Paper›PMID 39035040›Full record

ArticlePNAS nexus2024

Tyrosine phenol-lyase inhibitor quercetin reduces fecal phenol levels in mice.

Takuma Kobayashi, Shiori Oishi, Misaki Matsui, Kodai Hara, Hiroshi Hashimoto, Kenji Watanabe, Yasukiyo Yoshioka, Noriyuki Miyoshi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PNAS nexus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Takuma KobayashiGraduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Shizuoka, 4228526, Japan.ORCID https://orcid.org/0009-0006-6290-0719
Shiori OishiGraduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Shizuoka, 4228526, Japan.ORCID https://orcid.org/0009-0000-4067-9247
Misaki MatsuiSchool of Food and Nutritional Sciences, University of Shizuoka, Shizuoka, 4228526, Japan.
Kodai HaraDepartment of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, 4228526, Japan.ORCID https://orcid.org/0000-0002-1586-6312
Hiroshi HashimotoDepartment of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, 4228526, Japan.ORCID https://orcid.org/0000-0003-1503-6789
Kenji WatanabeDepartment of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, 4228526, Japan.ORCID https://orcid.org/0000-0002-0463-4831
Yasukiyo YoshiokaGraduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Shizuoka, 4228526, Japan.ORCID https://orcid.org/0009-0000-7097-1425
Noriyuki MiyoshiGraduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Shizuoka, 4228526, Japan.ORCID https://orcid.org/0000-0002-4233-4282

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tyrosine phenol-lyase (TPL), which is expressed in intestinal bacteria, catalyzes the formation of phenol from the substrate L-Tyr. Bacterial metabolite phenol and the sulfate conjugate (phenyl sulfate) are known as a type of uremic toxins, some of which exert cytotoxicity. Therefore, pathologically elevated phenol and phenyl sulfate levels are strongly implicated in the etiology and outcome of uremia. In this study, we explored the inhibitory effects of dietary polyphenols on TPL-catalyzed phenol production using a TPL activity assay. Quercetin, one of the most popular polyphenols, exhibited the strongest inhibitory activity (

Indexed as

intestinal bacteriaphenolquercetintyrosine phenol-lyase inhibitoruremic toxin

Identifiers

PMID39035040
PMCPMC11259132

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.