Evidence map›Paper›PMID 39035203›Full record

ArticleScience & public policy2024

Governing with public engagement: an anticipatory approach to human genome editing.

Dorit Barlevy, Eric Juengst, Jeffrey Kahn, Jonathan Moreno, Lauren Lambert, Alta Charo, Hervé Chneiweiss, Mahmud Farooque, David H Guston, Insoo Hyun and 5 more

Abstract read
In one paragraph

Article in Science & public policy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Genome editing between wonder and rejection.Frontiers in bioengineering and biotechnology · 2026
    Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Dorit BarlevyCenter for Medical Ethics and Health Policy, Baylor College of Medicine, Houston, TX 77030, United States.ORCID https://orcid.org/0000-0002-1478-0111
Eric JuengstCenter for Bioethics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States.
Jeffrey KahnBerman Institute of Bioethics, Johns Hopkins University, Baltimore, MD 21205, United States.ORCID https://orcid.org/0000-0003-2493-2016
Jonathan MorenoDepartment of Medical Ethics and Health Policy, University of Pennsylvania, Philadelphia, PA 19104, United States.
Lauren LambertCollege of Global Futures, Arizona State University, Tempe, AZ 85287, United States.
Alta CharoLaw School, University of Wisconsin-Madison, Madison, WI 53706, United States.
Hervé ChneiweissNeuroscience, Institute of Biology Paris Seine, CNRS UMR8246, INSERM U1130, Sorbonne Université, Paris 75252, France.
Mahmud FarooqueConsortium for Science, Policy & Outcomes, Arizona State University, Washington, DC 20006, United States.ORCID https://orcid.org/0000-0002-1694-5581
David H GustonSchool for the Future of Innovation in Society, Arizona State University, Tempe, AZ 85281, United States.
Insoo HyunMuseum of Science, Boston, MA 02114, United States.ORCID https://orcid.org/0000-0001-6605-7112
Paul S KnoepflerDepartment of Cell Biology & Human Anatomy, UC Davis School of Medicine, Davis, CA 95616, United States.
Cynthia SelinSchool for the Future of Innovation in Society, Arizona State University, Tempe, AZ 85281, United States.
Rebecca WilbanksUniversity Writing Program, Johns Hopkins University, Baltimore, MD 21218, United States.
Manar ZaghlulaInnovative Genomics Institute, University of California, Berkeley, CA 97404, United States.
Christopher Thomas ScottCenter for Medical Ethics and Health Policy, Baylor College of Medicine, Houston, TX 77030, United States.ORCID https://orcid.org/0000-0001-6502-1599

Funding

Self-governance in the Human Genome Editing Era: Can Science Rise to the Challenge?R01HG010332 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI SCOTT, CHRISTOPHER THOMAS, SELIN, CYNTHIA · 2019 to 2021
$1.9M
NHGRI NIH HHS R01 HG010332
6 · The paper itself

Abstract

In response to calls for public engagement on human genome editing (HGE), which intensified after the 2018 He Jiankui scandal that resulted in the implantation of genetically modified embryos, we detail an anticipatory approach to the governance of HGE. By soliciting multidisciplinary experts' input on the drivers and uncertainties of HGE development, we developed a set of plausible future scenarios to ascertain publics values-specifically, their hopes and concerns regarding the novel technology and its applications. In turn, we gathered a subset of multidisciplinary experts to propose governance recommendations for HGE that incorporate identified publics' values. These recommendations include: (1) continued participatory public engagement; (2) international harmonization and transparency of multiple governance levers such as professional and scientific societies, funders, and regulators; and (3) development of a formal whistleblower framework.

Indexed as

anticipatory governancehuman genome editingpublic engagement

Identifiers

PMID39035203
PMCPMC11258878

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.