Evidence map›Paper›PMID 39036427›Full record

ArticleNeurotrauma reports2024

Immunonutrition with Omega-3 Fatty Acid Supplementation in Severe TBI: Retrospective Analysis of Patient Characteristics and Outcomes.

Roy A Poblete, Jesus Pena, Grace Kuo, Fawaz Tarzi, Peggy L Nguyen, Steven Y Cen, Shelby Yaceczko, Stan G Louie, Meghan R Lewis, Matthew Martin and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurotrauma reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Roy A PobleteDepartment of Neurology, University of Southern California Keck School of Medicine, Los Angeles, California, USA.
Jesus PenaDepartment of Neurology, University of Southern California Keck School of Medicine, Los Angeles, California, USA.
Grace KuoDepartment of Neurology, University of Southern California Keck School of Medicine, Los Angeles, California, USA.
Fawaz TarziDepartment of Neurology, University of Southern California Keck School of Medicine, Los Angeles, California, USA.
Peggy L NguyenDepartment of Neurology, University of Southern California Keck School of Medicine, Los Angeles, California, USA.
Steven Y CenDepartment of Neurology, University of Southern California Keck School of Medicine, Los Angeles, California, USA.
Shelby YaceczkoUCLA Health, University of California, Los Angeles, California, USA.
Stan G LouieDepartment of Clinical Pharmacy, University of Southern California School of Pharmacy, Los Angeles, California, USA.
Meghan R LewisDepartment of Surgery, University of Southern California Keck School of Medicine, Los Angeles, California, USA.
Matthew MartinDepartment of Surgery, University of Southern California Keck School of Medicine, Los Angeles, California, USA.
Arun P AmarDepartment of Neurological Surgery, University of Southern California Keck School of Medicine, Los Angeles, California, USA.
Nerses SanossianDepartment of Neurology, University of Southern California Keck School of Medicine, Los Angeles, California, USA.
Gene SungDepartment of Neurology, University of Southern California Keck School of Medicine, Los Angeles, California, USA.
Patrick D LydenDepartment of Neurology, University of Southern California Keck School of Medicine, Los Angeles, California, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Early evidence-based medical interventions to improve patient outcomes after traumatic brain injury (TBI) are lacking. In patients admitted to the ICU after TBI, optimization of nutrition is an emerging field of interest. Specialized enteral nutrition (EN) formulas that include immunonutrition containing omega-3 polyunsaturated fatty acids (n-3 PUFAs) have been developed and are used for their proposed anti-inflammatory and proimmune properties; however, their use has not been rigorously studied in human TBI populations. A single-center, retrospective, descriptive observational study was conducted at the LAC + USC Medical Center. Patients with severe TBI (sTBI, Glasgow Coma Scale score ≤ 8) who remained in the ICU for ≥2 weeks and received EN were identified between 2017 and 2022 using the institutional trauma registry. Those who received immunonutrition formulas containing n-3 PUFAs were compared with those who received standard, polymeric EN with regard to baseline characteristics, clinical markers of inflammation and immune function, and short-term clinical outcomes. A total of 151 patients with sTBI were analyzed. Those who received immunonutrition with n-3 PUFA supplementation were more likely to be male, younger, Hispanic/Latinx, and have polytrauma needing non-central nervous system surgery. No differences in clinical markers of inflammation or infection rate were found. In multivariate regression analysis, immunonutrition was associated with reduced hospital length of stay (LOS). ICU LOS was also reduced in the subgroup of patients with polytrauma and TBI. This study identifies important differences in patient characteristics and outcomes associated with the EN formula prescribed. Study results can directly inform a prospective pragmatic study of immunonutrition with n-3 PUFA supplementation aimed to confirm the biomechanistic and clinical benefits of the intervention.

Indexed as

head traumainflammationnutritiontraumatic brain injury

Identifiers

PMID39036427
PMCPMC11257118

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.