Evidence map›Paper›PMID 39037672›Full record

ArticleEndocrine2024

Appraising the effectiveness of immune cells on thyroid cancer: a Mendelian randomization study.

Muge Liu, Ling Jin, Xiongsheng Xiao, Siyi Li, Changwei Zheng, Zhengde Chen, Zhi Zhang

Abstract read
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In one paragraph

Article in Endocrine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Muge Liu *Department of Vascular and Thyroid Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Ling Jin *Department of Breast Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Xiongsheng XiaoDepartment of Vascular and Thyroid Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Siyi LiDepartment of Vascular and Thyroid Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Changwei ZhengDepartment of Vascular and Thyroid Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Zhengde ChenDepartment of Vascular and Thyroid Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Zhi ZhangDepartment of Vascular and Thyroid Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China. zhangzhi-0714@gdmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe intricate interplay between the immune system and tumor plays a pivotal role in thyroid cancer (TC) pathogenesis, potentially influencing both the causation and therapeutic outcomes. Despite extensive research, existing literature offers ambiguous insights regarding the association between immune cell traits and thyroid cancer progression.

methodsTo elucidate the potential causal relationships, we conducted an integrated two-sample Mendelian randomization (MR) analysis. This study utilized publicly genetic datasets to explore the causalities between 731 immune cell traits (categorized into four trait types across seven panels) and thyroid cancer. We ensured the robustness of our findings through comprehensive sensitivity analyses, meticulously assessing potential sources of bias such as pleiotropy.

resultsAfter False Discovery Rate (FDR) correction, six immune cell traits were identified to be significantly associated with thyroid cancer risk (Inverse Variance Weighted, IVW): Absolute count of gamma delta T cells/ T-cell receptor gamma delta absolute count (TCRgd AC) 0.8464 (OR95% CI = 0.7477-0.9580, P = 0.0083, PFDR = 0.0103); CD8 on bright CD8 cells (CD8 on CD8br) 0.8867 (OR95% CI = 0.8159-0.9637, P = 0.0047, P

conclusionsOur study demonstrated the causalities between immune cell traits and thyroid cancers by Mendelian randomization study, thus guiding future mechanism studies.

Indexed as

Mendelian Randomization AnalysisThyroid NeoplasmsGenetic Predisposition to DiseaseHumansCausal relationshipsImmune cell traitMendelian RandomizationThyroid cancer

Identifiers

PMID39037672

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.