Evidence map›Paper›PMID 39039178›Full record

ReviewNature reviews. Cardiology2025

Standardization and clinical applications of retinal imaging biomarkers for cardiovascular disease: a Roadmap from an NHLBI workshop.

Emily Y Chew, Stephen A Burns, Alison G Abraham, Mathieu F Bakhoum, Joshua A Beckman, Toco Y P Chui, Robert P Finger, Alejandro F Frangi, Rebecca F Gottesman, Maria B Grant and 14 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Pathophysiology and Clinical Relevance of Microvascular Remodeling in Arterial Hypertension.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Emily Y ChewDivision of Epidemiology and Clinical Applications, National Eye Institute, NIH, Bethesda, MD, USA. echew@nei.nih.gov.ORCID 0000-0003-0999-9802
Stephen A BurnsSchool of Optometry, Indiana University, Bloomington, IN, USA.ORCID 0000-0001-5348-035X
Alison G AbrahamDepartment of Epidemiology, Colorado School of Public Health, University of Colorado, Aurora, CO, USA.
Mathieu F BakhoumDepartments of Ophthalmology and Visual Science and Pathology, School of Medicine, Yale University, New Haven, CT, USA.
Joshua A BeckmanDivision of Vascular Medicine, University of Southwestern Medical Center, Dallas, TX, USA.
Toco Y P ChuiDepartment of Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, NY, USA.
Robert P FingerDepartment of Ophthalmology, Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany.
Alejandro F FrangiDivision of Informatics, Imaging and Data Science (School of Health Sciences), Department of Computer Science (School of Engineering), University of Manchester, Manchester, UK.ORCID 0000-0002-2675-528X
Rebecca F GottesmanStroke Branch, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA.ORCID 0000-0002-9504-1256
Maria B GrantDepartment of Ophthalmology and Visual Sciences, School of Medicine, University of Alabama Heersink School of Medicine, Birmingham, AL, USA.
Henner HanssenDepartment of Sport, Exercise and Health, University of Basel, Basel, Switzerland.ORCID 0000-0001-5501-4205
Cecilia S LeeDepartment of Ophthalmology, University of Washington, Seattle, WA, USA.
Michelle L MeyerDepartment of Emergency Medicine, University of North Carolina, Chapel Hill, NC, USA.
Damiano RizzoniDepartment of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Alicja R RudnickaPopulation Health Research Institute, St. George's University of London, London, UK.
Joel S SchumanWills Eye Hospital, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, USA.ORCID 0000-0002-8885-3766
Sara B SeidelmannDepartment of Clinical Medicine, Columbia College of Physicians and Surgeons, Greenwich, CT, USA.
W H Wilson TangLerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.ORCID 0000-0002-8335-735X
Bishow B AdhikariDivision of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA.
Narasimhan DanthiDivision of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA.ORCID 0000-0002-3018-2330
Yuling HongDivision of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA.
Diane ReidDivision of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA.
Grace L ShenRetinal Diseases Program, Division of Extramural Science Programs, National Eye Institute, NIH, Bethesda, MD, USA.
Young S OhDivision of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA.

Funding

NOVEL GLAUCOMA DIAGNOSTICS FOR STRUCTURE AND FUNCTIONR01EY013178 · WILLS EYE HEALTH SYSTEM · 2000 to 2025
$3.0M
Stroke, Cognition and Neuroepidemiology SectionZIANS009435 · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · 2025 to 2025
$2.6M
Adaptive Optics Imaging of Human Retinal Vascular Structure and FunctionR01EY024315 · NEI · TRUSTEES OF INDIANA UNIVERSITY · PI Stephen A Burns · 2022 to 2024
$1.4M
NEI NIH HHS R01 EY013178NEI NIH HHS R01 EY024315
6 · The paper itself

Abstract

The accessibility of the retina with the use of non-invasive and relatively low-cost ophthalmic imaging techniques and analytics provides a unique opportunity to improve the detection, diagnosis and monitoring of systemic diseases. The National Heart, Lung, and Blood Institute conducted a workshop in October 2022 to examine this concept. On the basis of the discussions at that workshop, this Roadmap describes current knowledge gaps and new research opportunities to evaluate the relationships between the eye (in particular, retinal biomarkers) and the risk of cardiovascular diseases, including coronary artery disease, heart failure, stroke, hypertension and vascular dementia. Identified gaps include the need to simplify and standardize the capture of high-quality images of the eye by non-ophthalmic health workers and to conduct longitudinal studies using multidisciplinary networks of diverse at-risk populations with improved implementation and methods to protect participant and dataset privacy. Other gaps include improving the measurement of structural and functional retinal biomarkers, determining the relationship between microvascular and macrovascular risk factors, improving multimodal imaging 'pipelines', and integrating advanced imaging with 'omics', lifestyle factors, primary care data and radiological reports, by using artificial intelligence technology to improve the identification of individual-level risk. Future research on retinal microvascular disease and retinal biomarkers might additionally provide insights into the temporal development of microvascular disease across other systemic vascular beds.

Indexed as

BiomarkersCardiovascular DiseasesRetinaHumansNational Heart, Lung, and Blood Institute (U.S.)Retinal VesselsUnited StatesBiomarkers

Identifiers

PMID39039178

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.