ReviewBMC cancer2024
Symptom impact and health-related quality of life (HRQoL) assessment by cancer stage: a narrative literature review.
Review in BMC cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Effects of Immersive Virtual Reality Interventions on Symptom Management in Patients With Gastrointestinal Cancer: Systematic Review and Meta-Analysis of Randomized Controlled Trials.Journal of medical Internet research · 2026Pooled it
- Health-related quality of life domains relevant to people in Europe undergoing cancer treatment: a systematic review of qualitative research.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Pooled it
- Pooled it
- Acupuncture vs. Massage for Insomnia and Pain in Advanced Cancer: Exploratory RCT.Journal of pain and symptom management · 2026Trial
- Development and Application of a Psychological Expectations Scale for Patients With Middle- and Late-Stage Cervical Cancer in China.The journal of obstetrics and gynaecology research · 2026Article
- Digital Divide Among U.S. Adults with and without Cancer: Prevalence and Associated Factors.Journal of cancer education : the official journal of the American Association for Cancer Education · 2026Article
- Assessing the Impact on Health and Productivity Outcomes of Anti-PD-(L)1 Agents to Treat Early-Stage Cancers in Italy.Clinical drug investigation · 2026Article
- The Interplay of Quality of Life and Satisfaction with Nursing Care in Cancer Patients: A Narrative Review.Clinics and practice · 2026Review
- Decision regret in patients with rectal cancer undergoing multimodal therapy.Clinical and translational radiation oncology · 2026Article
- Factors Affecting Quality of Life of Thai Cervical Cancer Patients.The journal of obstetrics and gynaecology research · 2026Article
- Modelled impact of a multi-cancer early detection screening programme on cancer treatment in England.British journal of cancer · 2026Article
- Quality of life and associated factors among cancer patients receiving palliative care in Western Uganda: a cross-sectional study.BMC palliative care · 2026Article
- Impact of unmet needs on health-related quality of life among cancer survivors in Ulsan, Korea.BMC cancer · 2026Article
- Exploring the Dynamics of Perioperative Quality of Life in Patients with Pancreatic Cancer: A Cross-Lagged Panel Network Analysis.Annals of surgical oncology · 2026Article
- Implementing integrative nursing for oncology inpatients: a retrospective analysis of project-related routine data from 2021 to 2023.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Effects of Hospice Care on Anxiety, Depression, and Pain in Patients With Terminal Colon Adenocarcinoma: A Retrospective Cohort Study.Actas espanolas de psiquiatria · 2026Article
- Listening to Australians with ovarian cancer: a cross-sectional survey investigating clinical trials awareness, information access and participation.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- A mobile health app for real-time symptom monitoring in patients with cancer during COVID-19: feasibility, acceptability, and utility.BMC cancer · 2026Article
- Socioeconomic differences in labour market attachment after breast cancer: a population-based matched cohort study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Quality of life in cancer patients at the end of radiotherapy compared to a general population sample in Germany.International journal of cancer · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCancer stage at diagnosis is an important prognostic indicator for patient outcomes, with detection at later stages associated with increased mortality and morbidity. The impact of cancer stage on patient-reported outcomes is poorly understood. This research aimed to understand symptom burden and health related quality of life (HRQoL) impact by cancer stage for ten cancer types: 1) ovarian, 2) lung, 3) pancreatic, 4) esophageal, 5) stomach, 6) head and neck, 7) colorectal, 8) anal, 9) cervical, and 10) liver and bile duct.
methodsTen narrative literature reviews were performed to identify and collate published literature on patient burden at different stages of disease progression. Literature searches were conducted using an AI-assisted platform to identify relevant articles published in the last five (2017-2022) or ten years (2012-2022) where articles were limited. Conference abstracts were searched for the last two years (2020-2022). The geographic scope was limited to the United States, Canada, Europe, and global studies, and only journal articles written in English were included.
resultsA total of 26 studies with results stratified by cancer stage at diagnosis (and before treatment) were selected for the cancer types of lung, pancreatic, esophageal, stomach, head and neck, colorectal, anal, and cervical cancers. Two cancer types, ovarian cancer, and liver and bile duct cancer did not return any search results with outcomes stratified by disease stage. A general trend was observed for worse patient-reported outcomes in patients with cancer diagnosed at an advanced stage of disease compared with diagnosis at an earlier stage. Advanced disease stage was associated with greater symptom impact including general physical impairments such as pain, fatigue, and interference with functioning, as well as disease/region-specific symptom burden. Poorer HRQoL was also associated with advanced disease with commonly reported symptoms including anxiety and depression.
conclusionsOverall, the general trend for greater symptom burden and poorer HRQoL seen in late stage versus early-stage disease across the included cancer types supports the importance for early diagnosis and treatment to improve patient survival and decrease negative impacts on disease burden and HRQoL.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.