Evidence map›Paper›PMID 39040177›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Metformin reduces the risk of poor treatment outcomes among individuals with rifampicin-resistant tuberculosis and type-2 diabetes mellitus.

Argita D Salindri, Mariam Gujabidze, Maia Kipiani, Nino Lomtadze, Nestani Tukvadze, Zaza Avaliani, Henry M Blumberg, Hardy Kornfeld, Russell R Kempker, Matthew J Magee

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Argita D SalindriDepartment of Population Health Sciences, Georgia State University School of Public Health, Atlanta, GA, USA.ORCID 0000-0003-0962-0348
Mariam GujabidzeNational Center for Tuberculosis and Lung Diseases, Tbilisi, Georgia.
Maia KipianiNational Center for Tuberculosis and Lung Diseases, Tbilisi, Georgia.
Nino LomtadzeNational Center for Tuberculosis and Lung Diseases, Tbilisi, Georgia.
Nestani TukvadzeNational Center for Tuberculosis and Lung Diseases, Tbilisi, Georgia.
Zaza AvalianiNational Center for Tuberculosis and Lung Diseases, Tbilisi, Georgia.
Henry M BlumbergDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Hardy KornfeldDivision of Pulmonary, Allergy, and Critical Care, Department of Medicine, UMass Chan Medical School, Worcester, MA, USA.
Russell R KempkerDepartment of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA, USA.
Matthew J MageeDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.

Funding

Emory/Georgia TB Research Advancement Center (TRAC)P30AI168386 · EMORY UNIVERSITY · 2025 to 2025
$972k
Emory-Georgia TB Research Training ProgramD43TW007124 · EMORY UNIVERSITY · 2004 to 2025
$551k
FIC NIH HHS D43 TW007124FIC NIH HHS D43 TW009337FIC NIH HHS R21 TW011157NIAID NIH HHS P30 AI168386NIAID NIH HHS R03 AI133172NIAID NIH HHS R03 AI139871
6 · The paper itself

Abstract

We conducted a retrospective cohort study among individuals with rifampicin-resistant tuberculosis and diabetes to determine the association between metformin use and tuberculosis treatment outcomes. We found that individuals with metformin use had a significantly lower risk of poor tuberculosis treatment outcomes (adjusted RR=0.25, 95%CI 0.06 - 0.95) compared to those without.

Indexed as

diabetesmetforminpost-TB mortalityrifampicin-resistant TBsputum culture conversionTB treatment outcomes

Identifiers

PMID39040177
PMCPMC11261920

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.