ReviewOsteoarthritis and cartilage open2024
Non-pharmacological and non-surgical interventions to manage patients with knee osteoarthritis: An umbrella review 5-year update.
Review in Osteoarthritis and cartilage open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effect of tele-rehabilitation guided intervention on pain and function in middle-aged and older adult patients with knee osteoarthritis: a systematic review and meta-analysis.Frontiers in public health · 2025Pooled it
- Synergistic effects of low-intensity pulsed ultrasound and extracorporeal shock wave therapy in knee osteoarthritis: clinical outcomes and biochemical mechanisms.Journal of orthopaedic surgery and research · 2025Trial
- Food Supplements in Osteoarthritis: A Practical Framework for Discussing Evidence with Patients.Nutrients · 2026Review
- Article
- Mapping the Translational Research Structure of Photobiomodulation in Osteoarthritis: A Bibliometric Analysis.Bioengineering (Basel, Switzerland) · 2026Review
- The Effect of a Peer-Led Non-Pharmacological Pain-Management Program on Chronic Pain Intensity and Pain-Related Self-Efficacy in Older Adults with Osteoarthritis: A Quasi-Experimental Study.International journal of community based nursing and midwifery · 2026Article
- Evolving Strategies for Knee Osteoarthritis: A Narrative Review of Integrated Rehabilitation, Pharmacologic, and Joint-Preserving Interventions.Medical science monitor : international medical journal of experimental and clinical research · 2026Review
- Effects of an Exercise-Assisting Mobile App (Osteoarthritis-Rehabilitation Assistant [O-RA]) on Rehabilitation Outcomes in Older Adults: Randomized Controlled Parallel Clinical Trial.JMIR rehabilitation and assistive technologies · 2026Article
- Review
- A Pilot Study Investigating Clinical and Functional Outcomes of Novel Double-Coil rPMS in Knee Osteoarthritis.Biomedicines · 2026Article
- Bioactive-RichBiomedicines · 2026Article
- Non-Pharmacological Complementary and Alternative Therapies for Knee Osteoarthritis: A Scoping Review of Randomized Controlled Trials.Journal of pain research · 2026Review
- Implementation of clinical decision support tools for treatment selection in knee osteoarthritis: a scoping review.Therapeutic advances in musculoskeletal disease · 2026Review
- Comparative effectiveness of non-pharmacological interventions for knee osteoarthritis: protocol for a Bayesian Network meta-analysis.Systematic reviews · 2025Article
- Low-level laser therapy in osteoarthritic pain: A narrative review with an approach to integrated clinical use.Osteoarthritis and cartilage open · 2025Review
- Knee osteoarthritis rehabilitation: an integrated framework of exercise, nutrition, biomechanics, and physical therapist guidance-a narrative review.European journal of medical research · 2025Review
- Surgical Silence: When Choosing Not to Operate Is the Wisest Course of Action.Journal of orthopaedic case reports · 2025Article
- Metformin as a disease-modifying therapy in osteoarthritis: bridging metabolism and joint health.Frontiers in pharmacology · 2025Article
- Biomechanical and biological features of hyaluronic acid in combination with chondroitin and platelet rich plasma for regenerative medicine applications.Frontiers in bioengineering and biotechnology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This umbrella review aimed to summarize (and update) the effectiveness of non-pharmacological and non-surgical interventions for patients with knee osteoarthritis. Methods: The study followed the PRISMA guidelines. Manual and electronic databases were searched, to identify systematic reviews, following the P (knee osteoarthritis) I (non-pharmacological and non-surgical treatments) C (pharmacological, surgical, placebo, no intervention, or other non-pharmacological/non-surgical conservative treatments) O (pain, function, quality of life, and other knee-specific measures) model. The quality of evidence was assessed using the R-AMSTAR checklist and GRADE principles. Results: The search yielded 4086 records, of which 61 met the eligibility criteria. After evaluation with R-AMSTAR, four systematic reviews were excluded, resulting in 57 included systematic reviews, with an overall score of 29.6. The systematic reviews were published between 2018 and 2022 (29.8% in 2022), conducted in 19 countries (52.6% in China), and explored 24 distinct interventions. The systematic reviews encompassed 714 trials (mean of 13 ± 7.7 studies per systematic review), and 59,343 participants (mean 1041 ± 1002 per systematic review, and 82 ± 59.2 per study). The majority of participants were older obese women (61.6 ± 4.2 years, 30.2 ± 3.6 kg/m Conclusions: Based on the systematic reviews findings, Diet Therapy, Patient Education, and Resistance Training are strongly supported as core interventions for managing patients with knee osteoarthritis. Aquatic Therapy, Balance Training, Balneology, Dietary Supplements, Extracorporeal Shockwave Therapy, and Tai Ji show moderate support. For other interventions, the evidence quality was low, results were mixed or inconclusive, or there was not sufficient efficacy to support their use.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.