Evidence map›Paper›PMID 39041039›Full record

ArticleResearch square2025

A hypothalamic circuit for circadian regulation of corticosterone secretion.

Oscar D Ramirez-Plascencia, Roberto De Luca, Natalia L S Machado, Dominique Eghlidi, Mudasir A Khanday, Sathyajit S Bandaru, Francesca Raffin, Nina Vujovic, Elda Arrigoni, Clifford B Saper

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Oscar D Ramirez-PlascenciaDepartment of Neurology, Division of Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.ORCID 0000-0002-6862-4974
Roberto De LucaDepartment of Neurology, Division of Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.ORCID 0000-0001-8105-426X
Natalia L S MachadoDepartment of Neurology, Division of Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.ORCID 0000-0001-8750-2676
Dominique EghlidiDepartment of Neurology, Division of Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
Mudasir A KhandayDepartment of Neurology, Division of Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.ORCID 0000-0002-1619-4159
Sathyajit S BandaruDepartment of Neurology, Division of Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
Francesca RaffinDepartment of Neurology, Division of Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
Nina VujovicDivision of Sleep Medicine, Harvard Medical School, Boston, MA 02215, USA.ORCID 0000-0001-8149-0782
Elda ArrigoniDepartment of Neurology, Division of Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.ORCID 0000-0002-4391-6700
Clifford B SaperDepartment of Neurology, Division of Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.ORCID 0000-0002-5788-3014

Funding

Project 5: Novel strategies to prevent opioid-induced hypoventilation during sleep and identification of underlying mechanismsP01HL149630 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI DAVID ANDREW WELLMAN · 2020 to 2026
$22.3M
Circuitry for Circadian RhythmsR01NS072337 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SAPER, CLIFFORD B · 2010 to 2023
$4.8M
Hypothalamic arousal systemsR01NS085477 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SAPER, CLIFFORD B · 2014 to 2018
$2.8M
Neuronal Circuit Controlling Sleep-Promoting Ventrolateral Preoptic NeuronsR01NS122589 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Elda Arrigoni · 2022 to 2026
$1.8M
The Role of Neurotensin-Expressing Neurons of the Extended Ventrolateral Preoptic Nucleus in REM Sleep RegulationR03NS128993 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI DE LUCA, ROBERTO · 2023 to 2024
$173k
NHLBI NIH HHS P01 HL149630NINDS NIH HHS R01 NS072337NINDS NIH HHS R01 NS085477NINDS NIH HHS R01 NS122589NINDS NIH HHS R03 NS128993
6 · The paper itself

Abstract

The secretion of cortisol in humans and corticosterone (Cort) in rodents follows a daily rhythm which is important in readying the individual for daily activity. This rhythm is orchestrated by the suprachiasmatic nucleus (SCN), but how it ultimately regulates the circadian rhythm of activity of neurons in the paraventricular nucleus of the hypothalamus that produce corticotropin-releasing hormone (PVH

Indexed as

corticosteronecorticotropin-releasing hormonedorsomedial hypothalamus and paraventricular hypothalamus

Identifiers

PMID39041039
PMCPMC11261983

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.