Evidence map›Paper›PMID 39042673›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Molecular mechanisms of proteoglycan-mediated semaphorin signaling in axon guidance.

Farahdokht Nourisanami, Margarita Sobol, Zhuoran Li, Matej Horvath, Karolina Kowalska, Atul Kumar, Jonas Vlasak, Nicola Koupilova, David J Luginbuhl, Liqun Luo and 1 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Farahdokht Nourisanami *Department of Cell Biology, Faculty of Science, Charles University, Prague 128 43, Czechia.
Margarita Sobol *Department of Cell Biology, Faculty of Science, Charles University, Prague 128 43, Czechia.ORCID 0000-0003-3363-9460
Zhuoran Li *HHMI, Department of Biology, Stanford University, Stanford, CA 94305.ORCID 0009-0007-2979-5678
Matej HorvathDepartment of Cell Biology, Faculty of Science, Charles University, Prague 128 43, Czechia.ORCID 0000-0001-9741-3693
Karolina KowalskaDepartment of Cell Biology, Faculty of Science, Charles University, Prague 128 43, Czechia.
Atul KumarDepartment of Cell Biology, Faculty of Science, Charles University, Prague 128 43, Czechia.
Jonas VlasakDepartment of Cell Biology, Faculty of Science, Charles University, Prague 128 43, Czechia.ORCID 0009-0008-9359-5838
Nicola KoupilovaDepartment of Cell Biology, Faculty of Science, Charles University, Prague 128 43, Czechia.ORCID 0009-0004-2832-0580
David J LuginbuhlHHMI, Department of Biology, Stanford University, Stanford, CA 94305.
Liqun LuoHHMI, Department of Biology, Stanford University, Stanford, CA 94305.ORCID 0000-0001-5467-9264
Daniel RozbeskyDepartment of Cell Biology, Faculty of Science, Charles University, Prague 128 43, Czechia.ORCID 0000-0001-6546-8219

Funding

Assembly of the Central Olfactory Networks in DrosophilaR01DC005982 · NIDCD · STANFORD UNIVERSITY · PI LIQUN LUO · 2003 to 2026
$8.1M
Czech Science Foundation 21-27204 MFoundation for the National Institutes of Health (FNIH) R01-DC005982NIDCD NIH HHS R01 DC005982
6 · The paper itself

Abstract

The precise assembly of a functional nervous system relies on axon guidance cues. Beyond engaging their cognate receptors and initiating signaling cascades that modulate cytoskeletal dynamics, guidance cues also bind components of the extracellular matrix, notably proteoglycans, yet the role and mechanisms of these interactions remain poorly understood. We found that

Indexed as

Axon GuidanceDrosophila ProteinsProteoglycansSemaphorinsSignal TransductionAnimalsAxonsBinding SitesDrosophila melanogasterGlycosaminoglycansOlfactory Receptor NeuronsProtein BindingDrosophila ProteinsGlycosaminoglycansProteoglycansSemaphorinsaxon guidanceglycosaminoglycansSema2bsemaphorinsemaphorin bridge model

Identifiers

PMID39042673
PMCPMC11295036

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.