Evidence map›Paper›PMID 39042693›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Zfp106 binds to G-quadruplex RNAs and inhibits RAN translation and formation of RNA foci caused by G4C2 repeats.

Barbara Celona, Sally E Salomonsson, Haifan Wu, Bobo Dang, Huong T Kratochvil, Claire D Clelland, William F DeGrado, Brian L Black

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Microprotein Regulates G-quadruplex Driven RNA Aggregation.bioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Targeting GeneInternational journal of molecular sciences · 2025
    Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Barbara CelonaCardiovascular Research Institute, University of California, San Francisco, CA 94143.ORCID 0000-0001-5391-8155
Sally E SalomonssonWeill Institute for Neurosciences, University of California, San Francisco, CA 94143.
Haifan WuCardiovascular Research Institute, University of California, San Francisco, CA 94143.
Bobo DangCardiovascular Research Institute, University of California, San Francisco, CA 94143.ORCID 0000-0003-1962-8677
Huong T KratochvilCardiovascular Research Institute, University of California, San Francisco, CA 94143.
Claire D ClellandWeill Institute for Neurosciences, University of California, San Francisco, CA 94143.ORCID 0000-0002-9112-2278
William F DeGradoCardiovascular Research Institute, University of California, San Francisco, CA 94143.ORCID 0000-0003-4745-263X
Brian L BlackCardiovascular Research Institute, University of California, San Francisco, CA 94143.

Funding

Resource Core II: In Vivo CoreU19NS132303 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI NIREN MURTHY · 2023 to 2026
$19.7M
Project 3: Control of cardiac transcription by MEF2 and myocardinP01HL146366 · NHLBI · J. DAVID GLADSTONE INSTITUTES · PI BLACK, BRIAN L · 2019 to 2023
$13.7M
Deciphering the relationship between structure, dynamics and function in helical bundle proteinsR35GM122603 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WILLIAM DEGRADO · 2017 to 2026
$7.1M
Generation and analysis of mouse models to define the roles of the ALS-associated factor Zfp106/ZNF106 in neurodegenerationR01NS126499 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Brian L Black · 2024 to 2026
$1.2M
CRISPR-Cas9 editing in C9orf72 patient derived iPSCK08NS112330 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CLELLAND, CLAIRE · 2020 to 2024
$1.2M
Optimization of CRISPR genome editor and its delivery strategy for C9orf72 frontotemporal dementiaU01NS134062 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CLELLAND, CLAIRE, GONG, SHAOQIN - · 2023 to 2023
$870k
The role of the sub-endothelial niche in hemogenic endothelial specificationR01DK119621 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BLACK, BRIAN L · 2019 to 2021
$870k
Proton Conduction Pathways in Proton Channel ProteinsK99GM138753 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRATOCHVIL, HUONG TRAN · 2020 to 2021
$194k
HHS | National Institutes of Health (NIH) K99GM138753HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL146366HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK119621HHS | NIH | National Institute of General Medical Sciences (NIGMS) GM122603HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) NS126499HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) U01NS134062HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) U19NS132303NHLBI NIH HHS P01 HL146366NIDDK NIH HHS R01 DK119621NIGMS NIH HHS K99 GM138753NIGMS NIH HHS R35 GM122603NINDS NIH HHS K08 NS112330NINDS NIH HHS R01 NS126499NINDS NIH HHS U01 NS134062NINDS NIH HHS U19 NS132303U.S. Department of Defense (DOD) AL210129
6 · The paper itself

Abstract

Expansion of intronic GGGGCC repeats in the

Indexed as

Amyotrophic Lateral SclerosisC9orf72 ProteinG-QuadruplexesRNARNA-Binding ProteinsAdaptor Proteins, Signal TransducingAnimalsDNA Repeat ExpansionFrontotemporal DementiaHumansMiceNerve Tissue ProteinsProtein BindingProtein BiosynthesisAdaptor Proteins, Signal TransducingC9orf72 ProteinC9orf72 protein, humanNerve Tissue ProteinsRNARNA-Binding ProteinsZfp106 protein, mouseamyotrophic lateral sclerosisC9orf72G-quadruplexRAN translationRNA-binding protein

Identifiers

PMID39042693
PMCPMC11295049

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.