Evidence map›Paper›PMID 39043443›Full record

ReviewDiabetes & metabolism journal2024

Protein Arginine Methyltransferases: Emerging Targets in Cardiovascular and Metabolic Disease.

Yan Zhang, Shibo Wei, Eun-Ju Jin, Yunju Jo, Chang-Myung Oh, Gyu-Un Bae, Jong-Sun Kang, Dongryeol Ryu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Diabetes & metabolism journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yan ZhangDepartment of Molecular Cell Biology, Single Cell Network Research Center, Sungkyunkwan University, Suwon, Korea.
Shibo WeiDepartment of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, Korea.
Eun-Ju JinDepartment of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, Korea.
Yunju JoDepartment of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, Korea.
Chang-Myung OhDepartment of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, Korea.
Gyu-Un BaeMuscle Physiome Institute, College of Pharmacy, Sookmyung Women's University, Seoul, Korea.
Jong-Sun KangDepartment of Molecular Cell Biology, Single Cell Network Research Center, Sungkyunkwan University, Suwon, Korea.
Dongryeol RyuDepartment of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, Korea.

Funding

Gwangju Institute of Science and TechnologyMinistry of Science and ICTNational Research Foundation of Korea 2022K2A9A1A06091879National Research Foundation of Korea 2022R1I1A1A01063460National Research Foundation of Korea 2023R1A2C3006220National Research Foundation of Korea RS-2023-00261370
6 · The paper itself

Abstract

Cardiovascular diseases (CVDs) and metabolic disorders stand as formidable challenges that significantly impact the clinical outcomes and living quality for afflicted individuals. An intricate comprehension of the underlying mechanisms is paramount for the development of efficacious therapeutic strategies. Protein arginine methyltransferases (PRMTs), a class of enzymes responsible for the precise regulation of protein methylation, have ascended to pivotal roles and emerged as crucial regulators within the intrinsic pathophysiology of these diseases. Herein, we review recent advancements in research elucidating on the multifaceted involvements of PRMTs in cardiovascular system and metabolic diseases, contributing significantly to deepen our understanding of the pathogenesis and progression of these maladies. In addition, this review provides a comprehensive analysis to unveil the distinctive roles of PRMTs across diverse cell types implicated in cardiovascular and metabolic disorders, which holds great potential to reveal novel therapeutic interventions targeting PRMTs, thus presenting promising perspectives to effectively address the substantial global burden imposed by CVDs and metabolic disorders.

Indexed as

Cardiovascular DiseasesMetabolic DiseasesProtein-Arginine N-MethyltransferasesAnimalsHumansMethylationProtein-Arginine N-MethyltransferasesCardiovascular diseasesMetabolic diseasesMethylationProtein-arginine N-methyltransferases

Identifiers

PMID39043443
PMCPMC11307121

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.