Evidence map›Paper›PMID 39043734›Full record

ArticleScientific reports2024

Extraction optimization and reactivity of 7α-acetoxy-6β-hydroxyroyleanone and ability of its derivatives to modulate PKC isoforms.

Vera M S Isca, Gabrielle Bangay, Salvatore Princiotto, Lucília Saraíva, Daniel J V A Dos Santos, Alfonso T García-Sosa, Patrícia Rijo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Vera M S IscaCBIOS - Center for Research in Biosciences and Health Technologies, Universidade Lusófona, 1749-024, Lisboa, Portugal.
Gabrielle BangayCBIOS - Center for Research in Biosciences and Health Technologies, Universidade Lusófona, 1749-024, Lisboa, Portugal.
Salvatore PrinciottoCBIOS - Center for Research in Biosciences and Health Technologies, Universidade Lusófona, 1749-024, Lisboa, Portugal.
Lucília SaraívaLAQV/REQUIMTE, Laboratório de Microbiologia, Departamento de Ciências Biológicas, Faculdade de Farmácia, Universidade do Porto, 4050-313, Porto, Portugal.
Daniel J V A Dos SantosCBIOS - Center for Research in Biosciences and Health Technologies, Universidade Lusófona, 1749-024, Lisboa, Portugal.
Alfonso T García-SosaInstitute of Chemistry, University of Tartu, 54011, Tartu, Estonia. alfonso.tlatoani.garcia.sosa@ut.ee.
Patrícia RijoCBIOS - Center for Research in Biosciences and Health Technologies, Universidade Lusófona, 1749-024, Lisboa, Portugal. patricia.rijo@ulusofona.pt.

Funding

Estonian Research Council PRG1509Fundação para a Ciência e a Tecnologia UIDB/50006/2020 DOI 10.54499/UIDB/50006/2020, DOI 10.54499/UIDP/04567/2020 and DOI 10.54499/UIDB/04567/2020 and PhD grant SFRH/BD/137671/2018
6 · The paper itself

Abstract

Protein kinase C is a family of kinases that play important roles in carcinogenesis. Medicinal plants from Plectranthus spp. (Lamiaceae) are a well-known source of interesting abietanes, such as 7α-acetoxy-6β-hydroxyroyleanone (Roy). This study aimed to extract and isolate Roy from P. grandidentatus Gürke, comparing two extraction methods (CO

Indexed as

Protein Kinase CCell Line, TumorDiterpenesHumansIsoenzymesMCF-7 CellsMolecular Docking SimulationPlant Extracts7alpha-acetoxy-6beta-hydroxyroyleanoneDiterpenesIsoenzymesPlant ExtractsProtein Kinase C

Identifiers

PMID39043734
PMCPMC11266714

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.