Evidence map›Paper›PMID 39044806›Full record

ArticleFrontiers in aging neuroscience2024

Associations of endogenous estrogens, plasma Alzheimer's disease biomarkers, and

Katrina A Wugalter, Rachel A Schroeder, Rebecca C Thurston, Minjie Wu, Howard J Aizenstein, Ann D Cohen, M Ilyas Kamboh, Thomas K Karikari, Carol A Derby, Pauline M Maki

Abstract read
In one paragraph

Article in Frontiers in aging neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Evidence of APOE4-related brain vulnerabilities in verbal memory systems in midlife women.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Katrina A Wugalter *Department of Psychology, University of Illinois Chicago, Chicago, IL, United States.
Rachel A Schroeder *Department of Psychology, University of Illinois Chicago, Chicago, IL, United States.
Rebecca C ThurstonDepartments of Psychiatry, Epidemiology, Psychology, and Clinical and Translational Science, University of Pittsburgh, Pittsburgh, PA, United States.
Minjie WuDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States.
Howard J AizensteinDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States.
Ann D CohenDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States.
M Ilyas KambohDepartments of Psychiatry, Human Genetics, and Epidemiology, University of Pittsburgh, Pittsburgh, PA, United States.
Thomas K KarikariDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States.
Carol A DerbyThe Saul R. Korey Department of Neurology, Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY, United States.
Pauline M MakiDepartments of Psychiatry, Psychology and Obstetrics & Gynecology, University of Illinois Chicago, Chicago, IL, United States.

Funding

Plasma brain-derived tau: a novel Alzheimer’s disease-type neurodegeneration biomarker with potential to complete the AT(N) scheme in bloodR01AG083874 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Thomas K Karikari · 2023 to 2026
$14.5M
Alzheimer Diagnosis in older Adults with Chronic Conditions ADACC NetworkU24AG082930 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Nicole R. Fowler, Thomas K Karikari · 2023 to 2026
$7.3M
Menopausal Vasomotor Symptoms and Brain Aging in WomenRF1AG053504 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MAKI, PAULINE M, THURSTON, REBECCA C · 2016 to 2019
$4.1M
Menopausal Vasomotor Symptoms and Brain Aging in WomenR01AG053504 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MAKI, PAULINE M, THURSTON, REBECCA C · 2021 to 2025
$3.8M
Interdisciplinary Mentoring and Research in Womens Cardiovascular HealthK24HL123565 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI THURSTON, REBECCA C · 2014 to 2023
$1.0M
NHLBI NIH HHS K24 HL123565NIA NIH HHS R01 AG053504NIA NIH HHS R01 AG083874NIA NIH HHS RF1 AG053504
6 · The paper itself

Abstract

Background: Women carrying the Methods: Participants were enrolled in MsBrain, a cohort study of postmenopausal women ( Results: There was no main effect of Conclusion: We demonstrate that the brain volumes of postmenopausal women with poorer AD biomarker profiles benefit most from higher endogenous estrogen levels. These findings are driven by non-

Indexed as

amyloidAPOE4brain volumeendogenous estrogenspostmenopausetau

Identifiers

PMID39044806
PMCPMC11263297

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.