Evidence map›Paper›PMID 39045101›Full record

ArticleiScience2024

Loss of the polarity protein Par3 promotes dendritic spine neoteny and enhances learning and memory.

Mikayla M Voglewede, Elif Naz Ozsen, Noah Ivak, Matteo Bernabucci, Ruizhe Tang, Miao Sun, Zhiping P Pang, Huaye Zhang

Abstract read
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Neuronal connectivity, behavioral, and transcriptional alterations associated with the loss of MARK2.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
    Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Mikayla M VoglewedeDepartment of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
Elif Naz OzsenDepartment of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
Noah IvakDepartment of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
Matteo BernabucciDepartment of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
Ruizhe TangDepartment of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
Miao SunDepartment of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
Zhiping P PangDepartment of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
Huaye ZhangDepartment of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.

Funding

Polarity determinants in synaptic stability and plasticityR01NS089578 · NINDS · RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL · PI ZHANG, HUAYE · 2015 to 2019
$1.9M
An Orbitrap Tribrid mass spectrometer and nanoflow LC system to upgrade the proteomics facility at Rutgers-New Brunswick and Robert Wood Johnson Medical SchoolS10OD025140 · OD · RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL · PI LOBEL, PETER · 2019 to 2019
$921k
Shank3 and the Par polarity complex in neurodevelopmental disordersR21NS125782 · NINDS · RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL · PI ZHANG, HUAYE · 2021 to 2021
$413k
Mechanism of Par3-mediated regulation of dendritic spine plasticityF31NS122477 · NINDS · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI VOGLEWEDE, MIKAYLA · 2021 to 2023
$140k
NIH HHS S10 OD025140NINDS NIH HHS F31 NS122477NINDS NIH HHS R01 NS089578NINDS NIH HHS R21 NS125782
6 · The paper itself

Abstract

The Par3 polarity protein is critical for subcellular compartmentalization in different developmental processes. Variants of

Indexed as

Cellular neuroscienceMolecular neuroscience

Identifiers

PMID39045101
PMCPMC11263792

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.